| Enjoying hobbies is related to desirable cardiovascular effects. | |
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MedLine Citation:
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PMID: 20339972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An unhealthy lifestyle can increase the risk of cardiovascular disease. However, the mechanism by which lifestyle influences the development of cardiovascular disease remains unclear. Since coronary endothelial function is a predictor of cardiovascular prognosis, the goal of this study was to characterize the effect of enjoying hobbies on coronary endothelial function and cardiovascular outcomes. A total of 121 consecutive patients (76 men, 45 women) with almost normal coronary arteries underwent Doppler flow study of the left anterior descending coronary artery following sequential administration of papaverine, acetylcholine, and nitroglycerin. On the basis of responses to questionnaires, patients were divided into two groups; the Hobby group (n = 71) who enjoyed hobbies, and the Non-hobby group (n = 50) who had no hobbies. Cardiovascular outcomes were assessed at long-term follow-up using medical records or questionnaire surveys for major adverse cardiovascular events (MACE).The average follow-up period was 916 +/- 515 days. There were no significant differences in demographics when comparing the two groups. The percent change in coronary blood flow and coronary artery diameter induced by acetylcholine was significantly greater in the Hobby group than in the Non-hobby group (49% +/- 77% vs 25% +/- 37%, P < 0.05, 4% +/- 13% vs -3% +/- 20%, P < 0.05, respectively). The MACE rate was significantly lower in the Hobby group than in the Non-hobby group (P < 0.01). Enjoyment of hobbies was the only independent predictor of MACE (odds ratio 8.1 [95% confidence interval 1.60, 41.90], P = 0.01) among the variables tested. In the early stages of arteriosclerosis, enjoying hobbies may improve cardiovascular outcomes via its favorable effects on coronary endothelial function. |
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Authors:
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Keishi Saihara; Shuichi Hamasaki; Sanemasa Ishida; Tetsuro Kataoka; Akiko Yoshikawa; Koji Orihara; Masakazu Ogawa; Naoya Oketani; Tsuyoshi Fukudome; Nobuhiko Atsuchi; Takuro Shinsato; Hideki Okui; Takuro Kubozono; Hitoshi Ichiki; So Kuwahata; Etsuko Mizoguchi; Shoji Fujita; Takuro Takumi; Yuichi Ninomiya; Kaai Tomita; Chuwa Tei |
Publication Detail:
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Type: Journal Article Date: 2010-03-26 |
Journal Detail:
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Title: Heart and vessels Volume: 25 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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administration & dosage Adolescent Adult Aged Aged, 80 and over Cardiovascular Diseases / diagnosis, etiology, physiopathology, psychology* Coronary Angiography Coronary Circulation* / drug effects Coronary Vessels / drug effects, physiopathology*, ultrasonography Disease-Free Survival Echocardiography, Doppler Female Hobbies* Humans Kaplan-Meiers Estimate Life Style* Male Middle Aged Nitroglycerin / administration & dosage Odds Ratio Papaverine / administration & dosage Pleasure* Prognosis Proportional Hazards Models Quality of Life Questionnaires Risk Assessment Risk Factors Risk Reduction Behavior* Stress, Psychological / complications* Time Factors Vasodilation Vasodilator Agents / administration & dosage Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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