Document Detail

Enjoying hobbies is related to desirable cardiovascular effects.
MedLine Citation:
PMID:  20339972     Owner:  NLM     Status:  MEDLINE    
An unhealthy lifestyle can increase the risk of cardiovascular disease. However, the mechanism by which lifestyle influences the development of cardiovascular disease remains unclear. Since coronary endothelial function is a predictor of cardiovascular prognosis, the goal of this study was to characterize the effect of enjoying hobbies on coronary endothelial function and cardiovascular outcomes. A total of 121 consecutive patients (76 men, 45 women) with almost normal coronary arteries underwent Doppler flow study of the left anterior descending coronary artery following sequential administration of papaverine, acetylcholine, and nitroglycerin. On the basis of responses to questionnaires, patients were divided into two groups; the Hobby group (n = 71) who enjoyed hobbies, and the Non-hobby group (n = 50) who had no hobbies. Cardiovascular outcomes were assessed at long-term follow-up using medical records or questionnaire surveys for major adverse cardiovascular events (MACE).The average follow-up period was 916 +/- 515 days. There were no significant differences in demographics when comparing the two groups. The percent change in coronary blood flow and coronary artery diameter induced by acetylcholine was significantly greater in the Hobby group than in the Non-hobby group (49% +/- 77% vs 25% +/- 37%, P < 0.05, 4% +/- 13% vs -3% +/- 20%, P < 0.05, respectively). The MACE rate was significantly lower in the Hobby group than in the Non-hobby group (P < 0.01). Enjoyment of hobbies was the only independent predictor of MACE (odds ratio 8.1 [95% confidence interval 1.60, 41.90], P = 0.01) among the variables tested. In the early stages of arteriosclerosis, enjoying hobbies may improve cardiovascular outcomes via its favorable effects on coronary endothelial function.
Keishi Saihara; Shuichi Hamasaki; Sanemasa Ishida; Tetsuro Kataoka; Akiko Yoshikawa; Koji Orihara; Masakazu Ogawa; Naoya Oketani; Tsuyoshi Fukudome; Nobuhiko Atsuchi; Takuro Shinsato; Hideki Okui; Takuro Kubozono; Hitoshi Ichiki; So Kuwahata; Etsuko Mizoguchi; Shoji Fujita; Takuro Takumi; Yuichi Ninomiya; Kaai Tomita; Chuwa Tei
Publication Detail:
Type:  Journal Article     Date:  2010-03-26
Journal Detail:
Title:  Heart and vessels     Volume:  25     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  113-20     Citation Subset:  IM    
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
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MeSH Terms
Acetylcholine / administration & dosage
Aged, 80 and over
Cardiovascular Diseases / diagnosis,  etiology,  physiopathology,  psychology*
Coronary Angiography
Coronary Circulation* / drug effects
Coronary Vessels / drug effects,  physiopathology*,  ultrasonography
Disease-Free Survival
Echocardiography, Doppler
Kaplan-Meiers Estimate
Life Style*
Middle Aged
Nitroglycerin / administration & dosage
Odds Ratio
Papaverine / administration & dosage
Proportional Hazards Models
Quality of Life
Risk Assessment
Risk Factors
Risk Reduction Behavior*
Stress, Psychological / complications*
Time Factors
Vasodilator Agents / administration & dosage
Young Adult
Reg. No./Substance:
0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 58-74-2/Papaverine

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