Document Detail


Enhancing recovery from peripheral nerve injury using treadmill training.
MedLine Citation:
PMID:  21498059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Full functional recovery after traumatic peripheral nerve injury is rare. We postulate three reasons for the poor functional outcome measures observed. Axon regeneration is slow and not all axons participate. Significant misdirection of regenerating axons to reinnervate inappropriate targets occurs. Seemingly permanent changes in neural circuitry in the central nervous system are found to accompany axotomy of peripheral axons. Exercise in the form of modest daily treadmill training impacts all three of these areas. Compared to untrained controls, regenerating axons elongate considerably farther in treadmill trained animals and do so via an autocrine/paracrine neurotrophin signaling pathway. This enhancement of axon regeneration takes place without an increase in the amount of misdirection of regenerating axons found without training. The enhancement also occurs in a sex-dependent manner. Slow continuous training is effective only in males, while more intense interval training is effective only in females. In treadmill trained, but not untrained mice the extent of coverage of axotomized motoneurons is maintained, thus preserving important elements of the spinal circuitry.
Authors:
Arthur W English; Jennifer C Wilhelm; Manning J Sabatier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-12
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  193     ISSN:  1618-0402     ISO Abbreviation:  Ann. Anat.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-15     Completed Date:  2011-10-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  354-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier GmbH. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology
Central Nervous System / physiology
Female
Male
Mice
Nerve Growth Factors / physiology
Nerve Regeneration / physiology*
Neuronal Plasticity / physiology
Peripheral Nerve Injuries*
Peripheral Nerves / physiology*
Physical Conditioning, Animal / methods,  physiology*
Rats
Running / physiology
Sex Factors
Time Factors
Grant Support
ID/Acronym/Agency:
K12 GM000680/GM/NIGMS NIH HHS; K12GM000680/GM/NIGMS NIH HHS; NS057190/NS/NINDS NIH HHS; R01 NS057190/NS/NINDS NIH HHS; R01 NS057190-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Growth Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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