Document Detail


Enhancing penicillin fermentations by increased oxygen solubility through the addition of n-hexadecane.
MedLine Citation:
PMID:  18595052     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
n-Hexadecane was added to fermentation media to increase the medium oxygen solubilities, thus enhancing oxygen transfer rates in penicillin fermentations. For shake flask fermentations, cells were found to grow faster in the flasks with n-hexadecane than those without. The addition of n-hexadecane to penicillin fermentations was shown to significantly increase cell growth and penicillin production and reduce formation of mycelial pellets. The result was attributed to the enhancement of oxygen transfer in mycelial fermentations due to the higher oxygen solubilities of fermentation media achieved by adding n-hexadecane.
Authors:
C S Ho; L K Ju; R F Baddour
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biotechnology and bioengineering     Volume:  36     ISSN:  0006-3592     ISO Abbreviation:  Biotechnol. Bioeng.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  2008-07-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502021     Medline TA:  Biotechnol Bioeng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1110-8     Citation Subset:  -    
Affiliation:
Charles River Laboratories, Inc., Wilmington, Massachusetts 01887.
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