| Enhancing exposure therapy for anxiety disorders with glucocorticoids: from basic mechanisms of emotional learning to clinical applications. | |
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MedLine Citation:
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PMID: 19962269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current neurophysiological and psychological accounts view exposure therapy as the clinical analog of extinction learning that results in persistent modifications of the fear memory involved in the pathogenesis, symptomatology, and maintenance of anxiety disorders. Evidence from studies in animals and humans indicate that glucocorticoids have the potential to facilitate the processes that underlie extinction learning during exposure therapy. Particularly, glucocorticoids can restrict retrieval of previous aversive learning episodes and enhance consolidation of memory traces relating to non-fearful responding in feared situations. Thus, glucocorticoid treatment especially in combination with exposure therapy might be a promising approach to optimize treatment of anxiety disorders. This review examines the processes involved in aversive conditioning, fear learning and fear extinction, and how glucocorticoids might enhance restructuring of fear memories during therapy. |
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Authors:
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Doroth?e Bentz; Tanja Michael; Dominique J-F de Quervain; Frank H Wilhelm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-06 |
Journal Detail:
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Title: Journal of anxiety disorders Volume: 24 ISSN: 1873-7897 ISO Abbreviation: J Anxiety Disord Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710131 Medline TA: J Anxiety Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 223-30 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Clinical Psychology & Psychotherapy, Faculty of Psychology, University of Basel, CH-4055 Basel, Switzerland. dorothee.bentz@unibas.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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administration & dosage*,
pharmacology Anxiety Disorders / drug therapy, therapy* Combined Modality Therapy Conditioning (Psychology) / physiology Extinction, Psychological / physiology Fear Glucocorticoids / pharmacology Humans Hydrocortisone / administration & dosage*, pharmacology Implosive Therapy* Memory / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Glucocorticoids; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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