Document Detail


Enhancing effects of myristyl lactate and lauryl lactate on percutaneous absorption of indomethacin in rats.
MedLine Citation:
PMID:  2076576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The enhancing effects of myristyl lactate (ML) and lauryl lactate (LL) on the percutaneous absorption of indomethacin (ID) from test solutions in propylene glycol (PG) were investigated in rats. ID absorption was observed to be markedly enhanced by the addition of ML or LL to PG as compared with the control (PG alone). The marked enhancing effects were observed at concentrations greater than 3% ML and 3% LL in PG. In particular, the maximal enhancement of percutaneous absorption of ID was achieved at 5% ML and LL. To elucidate the mode of action of ML as an enhancer, the percutaneous absorption of ID through the skin pretreated with ML alone was investigated. It was suggested that ML acts on the stratum corneum to produce its effect.
Authors:
M Dohi; F Kaiho; A Suzuki; N Sekiguchi; N Nakajima; H Nomura; Y Kato
Related Documents :
16785756 - Different plasma levels of vascular endothelial growth factor and nitric oxide between ...
468976 - Oxytocin in maternal circulation and amniotic fluid during pregnancy.
9438906 - Is there circadian variation of plasma endothelin (et-1) in patients with systemic scle...
2471676 - A survey of the concentration of 19-oh f1 alpha/f2 alpha prostaglandins in the semen of...
20423986 - Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free th...
6158996 - Raised maternal serum and amniotic fluid alpha-fetoprotein levels associated with a pla...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  38     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-04-25     Completed Date:  1991-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  2877-9     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Excipients
Indomethacin / administration & dosage,  pharmacokinetics*
Lactates / pharmacology*
Male
Rats
Rats, Inbred Strains
Skin Absorption / drug effects*
Chemical
Reg. No./Substance:
0/Excipients; 0/Lactates; 1323-03-1/myristyl lactate; 53-86-1/Indomethacin; 6283-92-7/Eutanol G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Release characteristics of cisplatin chitosan microspheres and effect of containing chitin.
Next Document:  Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythro...