Document Detail


Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth.
MedLine Citation:
PMID:  8638090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to ascertain the effects of epidermal growth factor (EGF) on human cancer invasion abilities, three cell lines of human oral squamous cell carcinoma were studied using a phagokinetic track assay and zymography. EGF (1-100 ng/ml) was found to inhibit the growth but enhance the random motility of all three cell lines in a concentration-dependent fashion. Exposure to EGF, dose-dependently, led to an increased production of urokinase-type plasminogen activator and M(r) 92 kD matrix metalloproteinase by the same cells. These results strongly suggest that EGF may promote human squamous cell carcinoma invasion and metastasis.
Authors:
T Shibata; T Kawano; H Nagayasu; K Okumura; M Arisue; J Hamada; N Takeichi; M Hosokawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  17     ISSN:  1010-4283     ISO Abbreviation:  Tumour Biol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-07-10     Completed Date:  1996-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  168-75     Citation Subset:  IM    
Affiliation:
Department of Oral Surgery, Health Sciences University of Hokkaido, Japan.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / pathology*
Cell Division
Cell Movement / drug effects
Epidermal Growth Factor / pharmacology*
Extracellular Matrix / metabolism
Humans
Metalloendopeptidases / metabolism
Tumor Cells, Cultured
Urokinase-Type Plasminogen Activator / metabolism
Chemical
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor; EC 3.4.21.73/Urokinase-Type Plasminogen Activator; EC 3.4.24.-/Metalloendopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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