Document Detail

Enhancing the carotenoid content of atherosclerotic plaque: implications for laser therapy.
MedLine Citation:
PMID:  2709523     Owner:  NLM     Status:  MEDLINE    
Selective laser ablation of human atherosclerotic plaque is possible because endogenous carotenoid pigments found in atherosclerotic plaque confer a twofold preferential absorption of laser radiation at 450 to 500 nm. In this study, patients with carotid endarterectomy were pretreated with oral beta carotene to determine if the carotenoid content and therefore laser selectivity of plaque could be increased in vivo. Beta carotene-treated patients had a significant, nearly twofold increase in their plaque carotenoid concentration, which increased from 0.22 to 0.40 microgram beta carotene/mg cholesterol. These results suggest that selective ablation of atherosclerotic plaque may be enhanced by pretreating patients with doses of oral beta carotene for short periods of time.
G M LaMuraglia; M M Mathews-Roth; J A Parrish; W M Abbott; D C Brewster; D J McAuliffe; M R Prince
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  9     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
Vascular Surgery Unit, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Carotenoids / therapeutic use*
Carotid Artery Diseases / surgery*
Intracranial Arteriosclerosis / metabolism,  surgery*
Laser Therapy*
Middle Aged
beta Carotene
Grant Support
Reg. No./Substance:
36-88-4/Carotenoids; 7235-40-7/beta Carotene
Comment In:
J Vasc Surg. 1990 Feb;11(2):359-60   [PMID:  2105402 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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