Document Detail


Enhancing the MSC Therapeutic Response: Cell Localization and Support for Cartilage Repair.
MedLine Citation:
PMID:  22897343     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Articular cartilage is a complex, multi-layered biological composite material, comprised of chondrocytes encapsulated in a water based glycosaminoglycan matrix reinforced with collagen fibres. Once damaged by osteoarthritis or traumatic injury, this aneural, avascular tissue has little self-repair capacity. Over the last 20 years, cell therapies and tissue engineering strategies and have shown significant promise for the repair or regeneration of damaged cartilage. In particular mesenchymal stem cells (MSC) have great potential owing to their ability to create a reparative environment. Despite the fact, that there have been great strides in the design and development 3D scaffolds, there is an upper limit to the number of viable cells that can be delivered using current approaches. To this end, this review examines current strategies for optimizing MSC localization, evaluates their limitations and looks to other technologies to devise a combinatorial strategy for the creation of an MSC seeded composite structure that addresses both the mechanical and biological property requirements for enhanced cartilage repair.
Authors:
Sarah Bulman; Valerie Barron; Cynthia Coleman; Frank Barry
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  -     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Smith & Nephew, York, United Kingdom; sarah.bulman@smith-nephew.com.
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