Document Detail

Enhancing Guided Tissue Regeneration of Periodontal Defects by Using a Novel Perforated Barrier Membrane.
MedLine Citation:
PMID:  23003916     Owner:  NLM     Status:  Publisher    
Background: The present study was designed to determine whether exclusion of the gingival connective tissue and periosteum with contained stem cells has a positive or negative effect on periodontal regeneration by comparing the use of a novel modified perforated collagen membrane with a traditional cell occlusive barrier membrane. Methods: Twenty non-smoking patients with severe chronic periodontitis were included in the study. Single deep intrabony defects from each of the patients were randomly divided into 2 groups, as follows: occlusive bovine collagen membranes (OM control group, 10 sites) and modified perforated bovine collagen membranes (MPM test group, 10 sites). Plaque index, gingival index, probing depth (PD) , clinical attachment level (CAL), defect base level and crestal bone level were measured at baseline and were reassessed at six and nine months after therapy in order to evaluate the quantitative changes in the defect. Results: At 6 and 9 month observation periods, the MPM treated sites showed a statistically significant improvement in PD reduction and CAL gain compared to the OM control group. Defect base level was significantly reduced with no significant difference between the 2 groups at 6 and 9 months observation periods. Crestal bone level was significantly higher in the MPM group when compared to that of the OM group at both observation periods. The postoperative differences between the two groups were 2 mm and 1.7 mm at 6 and 9 months, respectively, in favor of the MPM treated sites. Conclusion: The present study demonstrated enhanced clinical outcomes when using novel modified perforated barrier membranes as compared with cell occlusive barrier membranes in guided tissue regeneration procedures. These results may be affected by the penetration of gingival connective tissue contained stem cells and periosteal cells and their differentiation into components of the attachment apparatus.
Ahmed Y Gamal; Vincent J Iacono
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Dental Medicine, Department of Periodontology, El Azhar University, Cairo, Egypt.
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