| Enhancement of ursodeoxycholic acid bioavailability by cross-linked sodium carboxymethyl cellulose. | |
| | |
MedLine Citation:
|
PMID: 10813547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The bioavailability of ursodeoxycholic acid from a new formulation based on drug-loaded cross-linked sodium carboxymethyl cellulose was studied in man. The plasma levels of ursodeoxycholic acid were determined by gas chromatography-mass spectrometry after derivatization and sample purification by solid-phase extraction. Capsules containing the drug/polymer system were prepared and compared with conventional commercial ursodeoxycholic acid capsules after single oral administration using a randomized crossover experimental design. Although the drug/polymer system improved the in-vitro dissolution rate of ursodeoxycholic acid in simulated intestinal fluid, statistical evaluation of the area under the plasma concentration curves indicated no significant difference in the extent of bioavailability between the two formulations (14.93+/-4.43 vs 14.95+/-5.79 microM h; P > 0.2). However, following the administration of the ursodeoxycholic acid/cross-linked sodium carboxymethyl cellulose system with an enteric-coated capsule, the mean area under the plasma concentration curve (27.60+/-10.11 microM h) was significantly higher than that obtained after treatment with the commercially available ursodeoxycholic acid capsule (16.24+/-8-38 microM h; P < 0.05). We concluded that improved intestinal absorption of the drug was obtained with enteric-coated capsules filled with the ursodeoxycholic acid/polymer system. Moreover, the simplicity of the preparation and the non-toxicity of the polymer used as the carrier represented additional advantages of this dosage form. |
| | |
Authors:
|
S Scalia; P Giunchedi; P Pazzi; U Conte |
Related Documents
:
|
22206437 - Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids. 2254627 - Influence of backward perfusion on ursodeoxycholate-induced choleresis in isolated in s... 11448637 - Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress cau... 7461467 - Lack of response to chenodeoxycholic acid in obese and non-obese patients. role of chol... 3040107 - A distinction in vitro between rat liver phosphatidate phosphatase and phospholipase c. 19133937 - Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal f... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 52 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-07-12 Completed Date: 2000-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 383-8 Citation Subset: IM |
Affiliation:
|
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy. sls@dns.unife.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Area Under Curve Biological Availability Capsules Carboxymethylcellulose / administration & dosage*, chemistry Cholagogues and Choleretics / chemistry, pharmacokinetics* Cross-Linking Reagents Cross-Over Studies Delayed-Action Preparations Female Gelatin Humans Male Ursodeoxycholic Acid / blood, chemistry, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
|
0/Capsules; 0/Cholagogues and Choleretics; 0/Cross-Linking Reagents; 0/Delayed-Action Preparations; 128-13-2/Ursodeoxycholic Acid; 9000-70-8/Gelatin; 9004-32-4/Carboxymethylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The encapsulation of bleomycin within chitosan based polymeric vesicles does not alter its biodistri...
Next Document: Chronic continuous cocaine infusion in rats: effect on urine cocaine, ecgonine methylester and benzo...