| Enhancement of the transformed shape phenotype by microtubule inhibitors and reversal by an inhibitor combination. | |
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MedLine Citation:
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PMID: 10717239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differences between transformed cells and their normal counterparts were defined by analyzing the cells' three-dimensional distribution of mass. Variables called factors, which explained the covariance of the real variables, were extracted from the data. We found that factors #4 (sharp, tapering projections) and #12 (rounding up), corresponded to G-protein functions. Then, the signature-type mass distribution of transformed cells was defined by factor values. Agents that caused signature-type mimicry could quantitatively shift factor values, for example, those affecting endocytic processing disproportionately reduced values of #4. Signature-type reversal was also observed and may be valuable in predicting the efficacy of chemotherapeutic agents. |
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Authors:
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C A Heckman; H K Plummer; R Mukherjee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of oncology Volume: 16 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-05-11 Completed Date: 2000-05-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 709-23 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403-0212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Transformation, Neoplastic* Colchicine / pharmacology* Insulin / pharmacology Microtubules / drug effects* Monensin / pharmacology Paclitaxel / pharmacology Phenotype Rats Tetradecanoylphorbol Acetate / pharmacology Valinomycin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA 78322-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 16561-29-8/Tetradecanoylphorbol Acetate; 17090-79-8/Monensin; 2001-95-8/Valinomycin; 33069-62-4/Paclitaxel; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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