Document Detail


Enhancement of the transformed shape phenotype by microtubule inhibitors and reversal by an inhibitor combination.
MedLine Citation:
PMID:  10717239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences between transformed cells and their normal counterparts were defined by analyzing the cells' three-dimensional distribution of mass. Variables called factors, which explained the covariance of the real variables, were extracted from the data. We found that factors #4 (sharp, tapering projections) and #12 (rounding up), corresponded to G-protein functions. Then, the signature-type mass distribution of transformed cells was defined by factor values. Agents that caused signature-type mimicry could quantitatively shift factor values, for example, those affecting endocytic processing disproportionately reduced values of #4. Signature-type reversal was also observed and may be valuable in predicting the efficacy of chemotherapeutic agents.
Authors:
C A Heckman; H K Plummer; R Mukherjee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of oncology     Volume:  16     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-11     Completed Date:  2000-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  709-23     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403-0212, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Transformation, Neoplastic*
Colchicine / pharmacology*
Insulin / pharmacology
Microtubules / drug effects*
Monensin / pharmacology
Paclitaxel / pharmacology
Phenotype
Rats
Tetradecanoylphorbol Acetate / pharmacology
Valinomycin / pharmacology
Grant Support
ID/Acronym/Agency:
CA 78322-01/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 16561-29-8/Tetradecanoylphorbol Acetate; 17090-79-8/Monensin; 2001-95-8/Valinomycin; 33069-62-4/Paclitaxel; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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