Document Detail

Enhancement of transdermal delivery of theophylline using microemulsion vehicle.
MedLine Citation:
PMID:  16926077     Owner:  NLM     Status:  MEDLINE    
A microemulsion vehicle had been studied as a possible matrix for transdermal delivery of theophylline. The existence of microemulsion regions were investigated in pseudo-ternary phase diagrams, and various microemulsion formulations were prepared using oleic acid, Cremophor RH40/Labrasol (1:2) and water. The optimal formulation of the microemulsion was evaluated in vitro using Franz diffusion cells. The droplet size of microemulsion was characterized by photo correlation spectroscopy. Pharmacokinetic study in vivo was conducted using rabbits, and the results indicated that AUC(0-->infinity) of transdermal administration was 1.65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline.
X Zhao; J P Liu; X Zhang; Y Li
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2006-07-21
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  327     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China.
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MeSH Terms
Administration, Cutaneous
Bronchodilator Agents / administration & dosage*,  pharmacokinetics
Oils / chemistry
Skin / drug effects,  metabolism
Skin Absorption
Surface-Active Agents / chemistry
Theophylline / administration & dosage*,  pharmacokinetics
Reg. No./Substance:
0/Bronchodilator Agents; 0/Emulsions; 0/Oils; 0/Surface-Active Agents; 0/Vehicles; 58-55-9/Theophylline

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