Document Detail


Enhancement of transdermal delivery of theophylline using microemulsion vehicle.
MedLine Citation:
PMID:  16926077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A microemulsion vehicle had been studied as a possible matrix for transdermal delivery of theophylline. The existence of microemulsion regions were investigated in pseudo-ternary phase diagrams, and various microemulsion formulations were prepared using oleic acid, Cremophor RH40/Labrasol (1:2) and water. The optimal formulation of the microemulsion was evaluated in vitro using Franz diffusion cells. The droplet size of microemulsion was characterized by photo correlation spectroscopy. Pharmacokinetic study in vivo was conducted using rabbits, and the results indicated that AUC(0-->infinity) of transdermal administration was 1.65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline.
Authors:
X Zhao; J P Liu; X Zhang; Y Li
Related Documents :
3890727 - In vitro activities of and mechanisms of resistance to antifol antimalarial drugs.
1324827 - Comparative in vitro study of nonoxynol-9: effects on human, bull and boar spermatozoa.
8928637 - Effect of intravenously applied canrenoate on ampullar endolymphatic potential.
8348677 - Improved synthesis of (5z)-7-(3-endo-[(benzenesulfonamido)-bicyclo[2.2.1]heptyl]hept-5-...
14760907 - Microorganisms growth in endodontic citric-acid solutions with and without microbiologi...
6597457 - Thromboxane synthesizing system in rat liver.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2006-07-21
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  327     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Bronchodilator Agents / administration & dosage*,  pharmacokinetics
Emulsions
Male
Mice
Oils / chemistry
Rabbits
Skin / drug effects,  metabolism
Skin Absorption
Solubility
Surface-Active Agents / chemistry
Theophylline / administration & dosage*,  pharmacokinetics
Vehicles
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Emulsions; 0/Oils; 0/Surface-Active Agents; 0/Vehicles; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A material-sparing method for simultaneous determination of true density and powder compaction prope...
Next Document:  The neonatal chest.