Document Detail


Enhancement of transdermal delivery of theophylline using microemulsion vehicle.
MedLine Citation:
PMID:  16926077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A microemulsion vehicle had been studied as a possible matrix for transdermal delivery of theophylline. The existence of microemulsion regions were investigated in pseudo-ternary phase diagrams, and various microemulsion formulations were prepared using oleic acid, Cremophor RH40/Labrasol (1:2) and water. The optimal formulation of the microemulsion was evaluated in vitro using Franz diffusion cells. The droplet size of microemulsion was characterized by photo correlation spectroscopy. Pharmacokinetic study in vivo was conducted using rabbits, and the results indicated that AUC(0-->infinity) of transdermal administration was 1.65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline.
Authors:
X Zhao; J P Liu; X Zhang; Y Li
Related Documents :
7107057 - Esca studies on heparin-like materials used for extracorporeal shunts.
6746967 - Self-statement induction of mood: some variations and cautions on the velten procedure.
21839077 - Maslinic acid, a natural triterpenoid compound from olea europaea, protects cortical ne...
3898987 - Detection of group b streptococci by agglutination testing from selective broth cultures.
17383177 - Supercritical co2 extraction of lipids from grain sorghum dried distillers grains with ...
18324727 - The first contribution of capillary electrophoresis to the study of abiotic origins of ...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2006-07-21
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  327     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Bronchodilator Agents / administration & dosage*,  pharmacokinetics
Emulsions
Male
Mice
Oils / chemistry
Rabbits
Skin / drug effects,  metabolism
Skin Absorption
Solubility
Surface-Active Agents / chemistry
Theophylline / administration & dosage*,  pharmacokinetics
Vehicles
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Emulsions; 0/Oils; 0/Surface-Active Agents; 0/Vehicles; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A material-sparing method for simultaneous determination of true density and powder compaction prope...
Next Document:  The neonatal chest.