Document Detail

Enhancement and safety of iomeprol-400 and iodixanol-320 in patients undergoing abdominal multidetector CT.
MedLine Citation:
PMID:  19064592     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to compare iomeprol-400 and iodixanol-320 for contrast enhancement and safety in patients undergoing liver multidetector CT (MDCT). 183 patients undergoing MDCT received equi-iodine (40 gI) iomeprol-400 (n = 91) or iodixanol-320 (n = 92) IV at 4 ml s(-1). Two off-site, independent, blinded readers determined the contrast density (in Hounsfield units (HUs)) in the abdominal aorta, inferior vena cava, portal vein and liver parenchyma during the arterial and portal phases. The mean contrast densities achieved were compared and 95% confidence intervals (CIs) estimated. Heart rate was measured at baseline and at post-dose peak, and a full safety assessment was performed. Study group demographics were comparable. Iomeprol-400 produced significantly greater enhancement of the aorta during the arterial phase (Reader 1: 337.3 HU vs 294.9 HU, 95% CI of difference (19.4, 65.5), p = 0.0004; Reader 2: 325.7 HU vs 295.3 HU, 95% CI of difference (6.6, 54.3), p = 0.01) and greater enhancement of the liver parenchyma during the portal venous phase (Reader 1: 115.1 H vs 108.6 HU, 95% CI of difference (0.27, 12.7), p = 0.04; Reader 2: 115.2 H vs 109.3 HU, 95% CI of difference (-0.1, 11.8), p = 0.05). Similar enhancement of the inferior vena cava and portal vein was noted. Comparably negligible increases in the mean heart rate were observed. Adverse events occurred in 1/91 (1.1%) subjects after iomeprol-400 and 4/92 (4.3%) subjects after iodixanol-320. In conclusion, iomeprol-400 produces greater arterial and portal phase enhancement and has a similarly negligible impact on heart rate and safety.
L Romano; L Grazioli; L Bonomo; J-R Xu; K-M Chen; R Dore; A Vanzulli; C Catalano
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2008-12-08
Journal Detail:
Title:  The British journal of radiology     Volume:  82     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-11     Citation Subset:  AIM; IM    
Diagnostic Imaging Department, Cardarelli Hospital, Naples, Italy.
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MeSH Terms
Aged, 80 and over
Anti-Infective Agents / administration & dosage,  pharmacology*
Contrast Media / administration & dosage,  adverse effects*
Drug Interactions
Heart Rate / drug effects
Injections, Intravenous
Iopamidol / administration & dosage,  adverse effects,  analogs & derivatives*
Liver / blood supply,  radiography*
Middle Aged
Portal Vein / radiography
Radiographic Image Enhancement / methods
Radiography, Abdominal
Tomography, X-Ray Computed
Triiodobenzoic Acids / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Contrast Media; 0/Triiodobenzoic Acids; 62883-00-5/Iopamidol; 78649-41-9/iomeprol; 92339-11-2/iodixanol

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