Document Detail

Enhancement of prostaglandin synthesizing activity by the treatment with sodium n-butyrate on cloned mastocytoma cells and various other tissue cell lines.
MedLine Citation:
PMID:  6775349     Owner:  NLM     Status:  MEDLINE    
We have compared the effects of n-butyrate on the prostaglandin synthesizing activities of cloned mouse mastocytoma cells, and various other tissue culture cell lines. Cells were treated with 1 mM n-butyrate for 40 hrs before harvesting. Prostaglandin synthesizing activities of the treated and the control cells were examined in a cell-free assay system. The treatment of some of the cloned mastocytoma cells with n-butyrate brought about the synthesis of prostaglandin D2, E2 and F2 alpha that were not synthesized by the control cells. The treatment of epithelial liver cells (BC-90) also resulted in the formation of 6-keto-prostaglandin F1 alpha which was not formed by the control cells. However, n-butyrate caused relatively small changes in the prostaglandin synthesizing activities of other clones of mastocytoma cells, mouse hepatoma cells, HeLa cells, rat granuloma cells and human embryonic fibroblasts. These data suggest differential effects of n-butyrate on different types of cultured cells.
M Kawamura; Y Koshihara; T Senshu; S Murota
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  19     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  659-69     Citation Subset:  IM    
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MeSH Terms
Butyrates / pharmacology*
Cell Division / drug effects
Clone Cells / drug effects
Mast-Cell Sarcoma / drug therapy*,  metabolism
Peptide Hydrolases / metabolism
Prostaglandins / biosynthesis*
Sarcoma, Experimental / drug therapy
Time Factors
Reg. No./Substance:
0/Butyrates; 0/Prostaglandins; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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