Document Detail


Enhancement of parkinsonian rigidity with contralateral hand activation.
MedLine Citation:
PMID:  21330199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver.
METHODS: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60° without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity.
RESULTS: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p=0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions.
CONCLUSIONS: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver.
SIGNIFICANCE: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD.
Authors:
Douglas Powell; Nicholas Hanson; A Joseph Threlkeld; Xiang Fang; Ruiping Xia
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-16
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  122     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2011-09-09     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1595-601     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Rehabilitation Science Research Laboratory, Department of Physical Therapy, Creighton University, Omaha, NE 68178, USA. douglaspowell@creighton.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Antiparkinson Agents / therapeutic use
Disability Evaluation
Electromyography
Female
Functional Laterality / drug effects,  physiology*
Hand / physiopathology*
Humans
Male
Middle Aged
Movement / physiology*
Muscle Rigidity / diagnosis,  drug therapy,  etiology*
Parkinson Disease / complications*,  drug therapy
Severity of Illness Index
Wrist Joint / innervation
Grant Support
ID/Acronym/Agency:
R15 HD061022-01A2/HD/NICHD NIH HHS; R15 HD061022-01A2S1/HD/NICHD NIH HHS; R15-HD061022/HD/NICHD NIH HHS; R15-HD061022-S1/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antiparkinson Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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