| Enhancement of noradrenaline-induced metabolic coronary dilatation by ethanol. | |
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MedLine Citation:
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PMID: 7363939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated perfused rat hearts receiving noradrenaline as a cardiostimulatory agent show the characteristic metabolic coronary dilatations which correlate with the inotropic effect elicited by noradrenaline. Addition of ethanol (20-400 mg/dl) to the perfusion fluid produced a concentration-dependent enhancement of the metabolic coronary dilatation. The latter was increased by 50% at about 125 mg ethanol/dl. Since the inotropic responses to noradrenaline were not affected by ethanol it is suggested that alcohol produces an alteration in the system that normally adapts the coronary flow to an increased cardiac performance. The effect of ethanol was fully reversible; removal of alcohol from the perfusion fluid restored the metabolic coronary dilatation in response to noradrenaline to control values. At high concentrations, 200-400 mg/dl, ethanol produced a small but significant reduction in contractility of the myocardium (11.1 +/- 2.4%). At these concentrations ethanol enhanced the noradrenaline induced metabolic coronary dilatation by about 100%. These data indicate that ethanol at concentrations that are commonly found in blood in vivo may be beneficial in facilitating the coronary reactions during cardiac exertion. However cardiodepressant effects, particularly at higher concentrations, must also be considered. |
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Authors:
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J Talesnik; S Belo; Y Israel |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 61 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-06-27 Completed Date: 1980-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 279-86 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Coronary Circulation / drug effects Coronary Vessels / drug effects* Drug Interactions Ethanol / pharmacology* Myocardial Contraction / drug effects Norepinephrine / pharmacology* Rats Stimulation, Chemical Vasodilator Agents* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 51-41-2/Norepinephrine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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