Document Detail


Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.
MedLine Citation:
PMID:  22632091     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Expression and implication of gangliosides in human osteosarcomas have not been systematically analyzed. In this study, we demonstrated that gangliosides, GD3 and GD2 are highly expressed in the majority of human osteosarcoma cell lines derived from oral cavity regions. Introduction of GD3 synthase cDNA into a GD3/GD2-negative (GD3/GD2-) subline of HOS resulted in the establishment of GD3/GD2+ transfectant cells.
Authors:
Hidenobu Shibuya; Kazunori Hamamura; Hiroshi Hotta; Yasuyuki Matsumoto; Yoshihiro Nishida; Hisashi Hattori; Keiko Furukawa; Minoru Ueda; Koichi Furukawa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-28
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Japanese Cancer Association.
Affiliation:
Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-0065; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466-0065.
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