Document Detail

Enhancement of lymphocytic SCE frequencies in patients with ovarian cancer.
MedLine Citation:
PMID:  3127735     Owner:  NLM     Status:  MEDLINE    
Sister chromatid exchange (SCE) frequencies were studied in normal and mutagen-treated lymphocyte cultures from patients with ovarian carcinoma and controls. The mean SCE value per cell in normal cultures from the patients was 7.84 which was significantly higher than 6.41 SCEs per cell observed in the controls (p less than 0.01). Similar SCE values obtained for mutagen (mitomycin C, MMC) treated cultures were somewhat lower for patients as compared to the controls, however, the difference was not significant. Cellular kinetics, expressed as average generation time (AGT), was suppressed in lymphocyte cultures from ovarian carcinoma patients as compared to the controls (p much less than 0.05). It was concluded that although baseline SCE rates in lymphocytes of patients with ovarian carcinoma were higher as compared to the controls, they have very limited application as a marker malignancy.
S G Adhvaryu; U M Rawal; J V Patel
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  35     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1988  
Date Detail:
Created Date:  1988-04-28     Completed Date:  1988-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Cell Biology Division, Gujarat Cancer and Research Institute, Ahmedabad, India.
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MeSH Terms
Carcinoma / genetics*
Cell Division / drug effects
Lymphocytes / cytology,  drug effects
Middle Aged
Mitomycins / pharmacology
Ovarian Neoplasms / genetics*
Sister Chromatid Exchange* / drug effects
Reg. No./Substance:
0/Mitomycins; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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