| Enhancement of liver parenchyma after injection of hepatocyte-specific MRI contrast media: a comparison of gadoxetic acid and gadobenate dimeglumine. | |
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MedLine Citation:
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PMID: 20099349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare enhancement of liver parenchyma in MR imaging after injection of hepatocyte-specific contrast media. MATERIALS AND METHODS: Patients (n = 295) with known/suspected focal liver lesions randomly received 0.025 mmol gadoxetic acid/kg body weight or 0.05 mmol gadobenate dimeglumine/kg body weight by means of bolus injection. MR imaging was performed before and immediately after injection, and in the delayed phase at approved time points (20 min after injection of gadoxetic acid and 40 min after injection of gadobenate dimeglumine). The relative liver enhancement for the overall population and a cirrhotic subgroup was compared in T1-weighted GRE sequences. An independent radiologist performed signal intensity measurements. Enhancement ratios were compared using confidence intervals (CIs). RESULTS: The relative liver enhancement in the overall population was superior with gadoxetic acid (57.24%) versus gadobenate dimeglumine (32.77%) in the delayed-imaging phase. The enhancement ratio between the contrast media was statistically significant at 1.75 (95% CI: 1.46-2.13). In the delayed phase, the enhancement of cirrhotic liver with gadoxetic acid (57.00%) was comparable to that in the overall population. Enhancement with gadobenate dimeglumine was inferior in cirrhotic liver parenchyma (26.85%). CONCLUSION: In the delayed, hepatocyte-specific phase, liver enhancement after injection of gadoxetic acid was superior to that obtained with gadobenate dimeglumine. |
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Authors:
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Antonella Filippone; Anthony Blakeborough; Josy Breuer; Luigi Grazioli; Simone Gschwend; Renate Hammerstingl; Gertraud Heinz-Peer; Thomas Kittner; Andrea Laghi; Edward Leen; Riccardo Lencioni; Olivier Lucidarme; Philipp Remplik; Philip J Robinson; Stefan G Ruehm; Fritz Schaefer; Christoforos Stoupis; Bernd Tombach; Pierre-Jean Valette; Christoph J Zech; Alexander Huppertz |
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Publication Detail:
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Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 356-64 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences and Bioimages, SS Annunziata Hospital, G. D'Annunzio University, Chieti, Italy. a.filippone@rad.unich.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Contrast Media Double-Blind Method Europe Gadolinium DTPA / diagnostic use* Humans Injections, Intra-Arterial Liver / pathology* Liver Neoplasms / pathology* Magnetic Resonance Imaging / methods* Meglumine / analogs & derivatives*, diagnostic use Middle Aged Organometallic Compounds / diagnostic use* Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadolinium ethoxybenzyl DTPA; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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