| Enhancement of intestinal growth in neonatal rats by epidermal growth factor in milk. | |
| | |
MedLine Citation:
|
PMID: 3500649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Breast milk has been shown to enhance neonatal intestinal growth. Because epidermal growth factor (EGF) is present in the milk of various mammalian species, the hypothesis was tested that EGF in rodent milk mediates, in part, the breast milk-enhanced intestinal growth in neonatal rat. Fifty-eight rat pups fed artificial formula that contained 1.2, 3.0, and 6.0 micrograms/ml EGF for 39 h had greater incorporation of [3H]thymidine into DNA and DNA content of intestine than 29 pups fed unsupplemented formula. Pups fed EGF for 5 days had significantly greater body weight, intestinal weight, length, and DNA content than control pups. Conversely, pups fed pooled rat milk containing rabbit-derived antibody to EGF for 39 h had intestines of lower weight that contained less DNA than animals fed rat milk containing normal rabbit serum. EGF appears to mediate in part, breast milk-enhanced neonatal intestinal growth. |
| | |
Authors:
|
C L Berseth |
Related Documents
:
|
3021949 - Effect of melatonin on the force of spontaneous contractions of in vitro rat small and ... 7807319 - Small bowel transplantation for pediatric short bowel syndrome: evaluation of the graft... 16926499 - Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppre... 2748789 - Is there circadian variation in villus height in rat small intestine? 19855979 - Loss of intestine during stoma closure: an experimental model comparing laparoscopic an... 8101699 - Genetic evidence for role of dpp iv in intestinal hydrolysis and assimilation of prolyl... 9351999 - Natural schistosoma mansoni infection in wild rats from guadeloupe: parasitological and... 14726149 - Effects of colchicine on liver functions of cirrhotic rats: beneficial effects result f... 15221689 - The effect of three phlebotomy techniques on hematological and clinical chemical evalua... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 253 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1987 Nov |
Date Detail:
|
Created Date: 1988-01-06 Completed Date: 1988-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G662-5 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn / growth & development* DNA / biosynthesis Epidermal Growth Factor / administration & dosage, pharmacology* Intestines / growth & development* Milk / physiology* Organ Size Rats |
| Chemical | |
Reg. No./Substance:
|
62229-50-9/Epidermal Growth Factor; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of epidermal growth factor on growth and postnatal development of the rabbit liver.
Next Document: Platelet-collagen adhesion enhances platelet aggregation induced by binding of VWF to platelets.