| Enhancement of hypophysectomy-induced dopamine receptor hypersensitivity in male rats by chronic haloperidol administration. | |
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MedLine Citation:
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PMID: 6537969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that hypophysectomy (HYPOX) would antagonize the development of a neuroleptic-induced dopamine receptor hypersensitivity, and suggested that the neuroleptic-induced dopamine receptor hypersensitivity may be mediated by the neuroleptic-induced hyperprolactinemia. Conversely, we and others have reported on the ability of HYPOX animals to develop a neuroleptic-induced dopamine receptor hypersensitivity. The present study was undertaken to define the possible role(s) of prolactin in the modulation of striatal dopamine receptor sensitivity. The data from these studies indicate: that HYPOX alone will result in the development of a striatal dopamine receptor hypersensitivity; that the HYPOX-induced dopamine receptor hypersensitivity could be increased by the chronic administration and withdrawal of haloperidol; that administration of prolactin to HYPOX rats would partially antagonize the development of the neuroleptic-induced dopamine receptor hypersensitivity; and that the administration of prolactin alone had minimal effects on the apomorphine-induced behavior or neurochemistry of the HYPOX animals. These results suggest that the neuroleptics do not require the presence of a pituitary secretion (specifically, prolactin) to induce a striatal dopamine receptor hypersensitivity; however, they do indicate that a pituitary secretion, perhaps prolactin, may have the ability to modulate striatal dopamine sensitivity. |
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Authors:
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J H Gordon; B I Diamond |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurochemistry Volume: 42 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-02-29 Completed Date: 1984-02-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 523-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / pharmacology Brain / drug effects, metabolism* Female Haloperidol / pharmacology* Humans Hypophysectomy* Kinetics Male Prolactin / pharmacology Rats Rats, Inbred Strains Receptors, Dopamine / drug effects, metabolism* Spiperone / metabolism Stereotyped Behavior / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 52-86-8/Haloperidol; 58-00-4/Apomorphine; 749-02-0/Spiperone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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