| Enhancement of human endometrial stromal decidualization by bestatin, an aminopeptidase-N inhibitor. | |
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MedLine Citation:
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PMID: 10923279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have re-evaluated the effects of bestatin, an aminopeptidase-N (CD13) inhibitor, on in vitro decidualization of normal human endometrial stromal cells by using an in vitro decidualization activity assay. Bestatin did not show any effects on the viability of both the decidualizing stromal cells co-stimulated with 8-Br-cAMP and bestatin and the 8-Br-cAMP-induced decidualized stromal cells, or on prolactin release from the decidualized stromal cells. However, bestatin dose-dependently enhanced prolactin release from the decidualizing stromal cells co-stimulated with 8-Br-cAMP and bestatin. These results indicate that bestatin enhances cAMP-mediated decidualization of human endometrial stromal cells and suggests that membrane aminopeptidase-N in the human endometrium is involved in the regulation of endometrial differentiation by inhibiting cAMP-mediated decidualization signals in endometrial stromal cells. |
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Authors:
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T Tanaka; N Umesaki; M Masuda; K Mizuno; S Ogita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 14 ISSN: 0951-3590 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Bromo Cyclic Adenosine Monophosphate
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pharmacology Antigens, CD13 / antagonists & inhibitors* Cells, Cultured Decidua / drug effects, physiology* Endometrium / physiology* Enzyme Inhibitors / pharmacology* Female Humans Leucine / analogs & derivatives*, pharmacology* Prolactin / analysis, secretion Stromal Cells / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 58970-76-6/bestatin; 61-90-5/Leucine; 9002-62-4/Prolactin; EC 3.4.11.2/Antigens, CD13 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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