| Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids. | |
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MedLine Citation:
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PMID: 19505400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation tissue formation, and stimulating re-epithelialization. Hyaluronan is a component of ECM and its anti-inflammatory effects and properties in enhancing wound closure are well known. In this study, we examined the effects of Aminogam gel, a new pharmacological preparation suggested to improve wound healing, composed of hyaluronic acid, proline, lysine, glycine and leucine, on human fibroblasts. Results show that fibroblasts treated with hyaluronic acid plus aminoacid solution increased their proliferative activity, collagen I and III, and fibronectin synthesis. Moreover, HA plus aminoacid solution increased the expression of transforming growth factor beta, connective tissue growth factor, interleukin-6 and -8, assayed by RT-PCR. These results suggested that Aminogam gel, involved in several stages of wound healing, as fibroblast proliferation, granulation tissue formation, ECM component deposition, and production of cytokines, may be a useful device to favour and accelerate wound closure. |
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Authors:
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M A Mariggiò; A Cassano; A Vinella; A Vincenti; R Fumarulo; L Lo Muzio; E Maiorano; D Ribatti; G Favia |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of immunopathology and pharmacology Volume: 22 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2009 Apr-Jun |
Date Detail:
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Created Date: 2009-06-09 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
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Languages: eng Pagination: 485-92 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy. mariada@dimo.uniba.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacology* Cell Cycle / drug effects Cell Proliferation / drug effects* Cells, Cultured Collagen Type I / biosynthesis*, genetics Collagen Type III / biosynthesis*, genetics Connective Tissue Growth Factor / metabolism Drug Combinations Fibroblasts / drug effects*, metabolism Fibronectins / biosynthesis Humans Hyaluronic Acid / pharmacology* Intercellular Signaling Peptides and Proteins / genetics, metabolism* Interleukin-6 / metabolism Interleukin-8 / metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors Transforming Growth Factor beta / metabolism Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/CTGF protein, human; 0/Collagen Type I; 0/Collagen Type III; 0/Drug Combinations; 0/Fibronectins; 0/IL6 protein, human; 0/IL8 protein, human; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 0/Interleukin-8; 0/Transforming Growth Factor beta; 139568-91-5/Connective Tissue Growth Factor; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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