Document Detail

Enhancement of exercise-induced asthma by cold air.
MedLine Citation:
PMID:  895804     Owner:  NLM     Status:  MEDLINE    
To study the possibility that the inhalation of cold air accentuates the bronchoconstrictor response to exercise in asthma, eight subjects exercised while breathing air at ambient or subfreezing temperatures. On a separate day, cold air was breathed at rest so as to isolate the effects of this stimulus. Pulmonary mechanics were measured before and after each experiment. In all subjects acute bronchoconstriction followed the control exercise challenge. With cold-air breathing, however, the magnitude of the response was markedly enhanced. Residual volume increased 158 per cent more than it did previously, and specific conductance and one-second forced expiratory volumes changed an additional 85 and 100 per cent, respectively. The effects of cold air at rest were very small. The results demonstrate a positive interaction of two common naturally occurring stimuli in the induction of asthmatic attacks, and constitute objective verification of a frequent clinical complaint.
R H Strauss; E R McFadden; R H Ingram; J J Jaeger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  297     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  743-7     Citation Subset:  AIM; IM; S    
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MeSH Terms
Airway Obstruction / physiopathology
Asthma* / physiopathology
Bronchi / physiopathology
Bronchial Spasm / physiopathology
Cold Temperature / adverse effects*
Constriction, Pathologic / physiopathology
Forced Expiratory Flow Rates
Forced Expiratory Volume
Heart / physiopathology
Heart Rate
Lung / physiopathology
Physical Exertion*
Total Lung Capacity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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