| Enhancement of cutaneous immune response to bacterial infection after low-level light therapy with 1072nm infrared light: A preliminary study. | |
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MedLine Citation:
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PMID: 21955546 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We investigated the photobiomodulation effects of 1072nm infrared light on the natural immune response involved in anti-bacterial and wound healing processes. Thirty mice infected with MRSA on the skin were divided into two groups. The experimental group was treated with 1072nm infrared light (irradiance: 20mW/cm(2), fluence: 12J/cm(2) for 10min) at 2, 4, 8, 12, 24h, 3 and 5days after inoculation and the control group with sham light. Serial changes of the mRNA levels of TLR2, IL-1β, TNF-α, IL-6, iNOS, MCP-1, TGF-β, bFGF and VEGF were studied by real time RT-PCR and those of the expression level of VEGF, bFGF, TGF-β and NF-κB by immunohistochemistry. The mRNA levels of the cytokines involved in the early phase of anti-bacterial immune response (IL-1β, TNF-α, IL-6, MCP-1) increased significantly in the 1072nm group, peaking between 12 and 24h post-inoculation. These levels normalized after 3-5days. Immunohistochemistry revealed a notably stronger expression of VEGF in the 1072nm group from 8-h post-inoculation to 5-day post-inoculation. We concluded that 1072nm infrared light had a photobiomodulation effect which resulted in an enhanced biological immune response to the bacterial infection by MRSA and also increased the expression of VEGF to a significant level. |
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Authors:
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Seung Yoon Celine Lee; In-Wha Seong; Ji-Seon Kim; Kyeong-A Cheon; Se Hun Gu; Hee Hwan Kim; Ki Ho Park |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: Journal of photochemistry and photobiology. B, Biology Volume: - ISSN: 1873-2682 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804966 Medline TA: J Photochem Photobiol B Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Microbiology, Korea University Medical School, 126-1, 5-Ga, Anam-Dong, Seongbuk-Gu, Seoul 136-705, South Korea; Hayan-nara Dermatology Group, 142-3, Sankok-dong, Bupyeong-ku, Incheon, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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