Document Detail


Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity.
MedLine Citation:
PMID:  22766390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generation of novelty and complexity in animal housing conditions which facilitates enhanced sensory and cognitive stimulation as well as physical activity. In a wide variety of animal models of brain disorders, environmental enrichment and exercise have been found to have beneficial effects, including cognitive enhancement, delayed disease onset, enhanced cellular plasticity and associated molecular processes. Potential cellular and molecular mechanisms will also be discussed, which have relevance for the future development of 'enviromimetics', drugs which could mimic or enhance the beneficial effects of environmental stimulation. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
Authors:
Terence Y C Pang; Anthony J Hannan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-02
Journal Detail:
Title:  Neuropharmacology     Volume:  64     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-02-11     Revised Date:  2013-03-06    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-28     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3010, Australia. terence.pang@florey.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animal Husbandry
Animals
Brain Diseases / physiopathology,  therapy*
Cognition*
Cognition Disorders / etiology,  prevention & control*
Cognitive Therapy / methods*
Combined Modality Therapy
Disease Models, Animal*
Humans
Learning
Memory
Mice
Motor Activity*
Rats
Running
Comments/Corrections
Erratum In:
Neuropharmacology. 2013 Feb;65:20

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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