| Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity. | |
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MedLine Citation:
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PMID: 22766390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generation of novelty and complexity in animal housing conditions which facilitates enhanced sensory and cognitive stimulation as well as physical activity. In a wide variety of animal models of brain disorders, environmental enrichment and exercise have been found to have beneficial effects, including cognitive enhancement, delayed disease onset, enhanced cellular plasticity and associated molecular processes. Potential cellular and molecular mechanisms will also be discussed, which have relevance for the future development of 'enviromimetics', drugs which could mimic or enhance the beneficial effects of environmental stimulation. This article is part of a Special Issue entitled 'Cognitive Enhancers'. |
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Authors:
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Terence Y C Pang; Anthony J Hannan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-07-02 |
Journal Detail:
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Title: Neuropharmacology Volume: 64 ISSN: 1873-7064 ISO Abbreviation: Neuropharmacology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-09-18 Completed Date: 2013-02-11 Revised Date: 2013-03-06 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
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Languages: eng Pagination: 515-28 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3010, Australia. terence.pang@florey.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animal Husbandry Animals Brain Diseases / physiopathology, therapy* Cognition* Cognition Disorders / etiology, prevention & control* Cognitive Therapy / methods* Combined Modality Therapy Disease Models, Animal* Humans Learning Memory Mice Motor Activity* Rats Running |
| Comments/Corrections | |
Erratum In:
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Neuropharmacology. 2013 Feb;65:20 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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