Document Detail


Enhancement of cocaine-induced hepatotoxicity by ethanol.
MedLine Citation:
PMID:  8462414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contribution of moderate ethanol consumption on cocaine induced hepatotoxicity and the role lipid peroxidation plays as a possible mechanism of such increased hepatotoxicity were evaluated. Male C57BL/6 mice were injected interperitoneally (i.p.) with increasing doses of cocaine, from 10 to 50 mg/kg body weight daily and simultaneously fed a liquid diet containing 28% of the calories as ethanol for 5 or 9 weeks. Control mice received saline (i.p.) and an isocaloric carbohydrate diet. Lipid fluorescence and conjugated dienes of extracted lipids and amounts of malondialdehyde (MDA) were evaluated as indices of lipoperoxidation. In addition, serum alanine aminotransferase and aspartate transaminase were measured as indicators of liver injury and cellular death. After 9 weeks, ethanol consumption during cocaine treatment increased hepatic lipid fluorescence, conjugated dienes and MDA about twofold over mice-treated with cocaine alone. Similarly, serum transaminases were 2.8-6-fold greater in mice consuming alcohol and treated with cocaine than in mice treated with cocaine only. Histological examination of livers from mice fed ethanol during treatment with cocaine exhibited increased hepatic injuries and necrosis. The data suggest that ethanol exacerbates cocaine-induced hepatotoxicity via increases in free radical activity and hepatic lipid peroxidation.
Authors:
O E Odeleye; R R Watson; C D Eskelson; D Earnest
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  31     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-30     Completed Date:  1993-04-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  253-63     Citation Subset:  IM    
Affiliation:
Department of Family and Community Medicine, Arizona Health Sciences Center, University of Arizona, Tucson 85724.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / pharmacokinetics,  toxicity*
Drug Synergism
Drug-Induced Liver Injury / pathology*
Ethanol / pharmacokinetics,  toxicity*
Hepatitis, Alcoholic / pathology*
Lipid Peroxidation / drug effects
Liver / pathology
Liver Function Tests
Male
Malondialdehyde / metabolism
Mice
Mice, Inbred C57BL
Phospholipids / metabolism
Grant Support
ID/Acronym/Agency:
AA-0837/AA/NIAAA NIH HHS; DA-04827/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Phospholipids; 50-36-2/Cocaine; 542-78-9/Malondialdehyde; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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