Document Detail


Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol.
MedLine Citation:
PMID:  3106695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indole-3-carbinol (I3C), a natural constituent of cruciferous vegetables, is an inhibitor in several experimental animal models of carcinogenesis by polynuclear aromatic hydrocarbons or aflatoxin B1 (AFB1) when administered prior to or during carcinogen exposure. For assessment of the postinitiation effects of I3C, rainbow trout were exposed to dietary I3C in two different protocols--before and during AFB1 exposure or after AFB1 exposure only. Preinitiation exposure to I3C reduced AFB1-initiated hepatocellular carcinomas in trout as previously reported, but post-initiation I3C exposure strongly enhanced the tumor incidence above the positive AFB1 control. These results reveal the need for additional research to elucidate the overall effect of I3C on chemical carcinogenesis.
Authors:
G S Bailey; J D Hendricks; D W Shelton; J E Nixon; N E Pawlowski
Related Documents :
9890655 - Biomarkers of free radical damage applications in experimental animals and in humans.
12731115 - Recommendations for future development in cattle transport in europe.
1987005 - Salt and hypertension--future directions.
16258595 - Specification of laboratory animal use in scientific articles: current low detail in th...
17375265 - Isolation of cellulolytic enzymes from moldy silage by new culture-independent strategy.
9695895 - Schizophrenia.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  78     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-23     Completed Date:  1987-06-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1
Aflatoxins
Animals
Brassica
Drug Synergism
Indoles / toxicity*
Liver Neoplasms, Experimental / chemically induced
Neoplasms, Experimental / chemically induced*
Trout
Grant Support
ID/Acronym/Agency:
CA-34732/CA/NCI NIH HHS; ES-00092/ES/NIEHS NIH HHS; ES-00210/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Indoles; 1162-65-8/Aflatoxin B1; 700-06-1/indole-3-carbinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mi...
Next Document:  Comparative evaluation of the efficacy of nitrosorbide and nitroglycerin in acute myocardial infarct...