Document Detail

Enhancement by food restriction of liver protein synthesis in the aging Fischer 344 rat.
MedLine Citation:
PMID:  3346519     Owner:  NLM     Status:  MEDLINE    
Age-related changes in liver protein synthesis of ad libitum fed and food-restricted SPF Fischer 344 rats have been measured. In ad libitum fed animals, valine incorporation increased from 3 to 6 mo of age, decreased to the 3-mo level at 12 mo, remained relatively constant through 18 mo, and then declined further at 24 mo of age. By 24 mo valine incorporation was 30% of the 6-mo value. Food restriction had no effect at 3 mo of age (6 wk of restriction) but at 6 mo the rate of valine incorporation was 35% greater than the control, an increment that was maintained throughout the life of the animal. Therefore, although food restriction does not prevent the age-related decline in protein synthesis, it does maintain the rate of liver valine incorporation at levels greater than those observed in the liver of the ad libitum fed animal.
W F Ward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of gerontology     Volume:  43     ISSN:  0022-1422     ISO Abbreviation:  J Gerontol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374762     Medline TA:  J Gerontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  B50-3     Citation Subset:  AIM; IM    
Department of Physiology, University of Texas Health Science Center, San Antonio.
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MeSH Terms
Age Factors
Body Weight
Liver / anatomy & histology,  metabolism*
Organ Size
Protein Biosynthesis*
Rats, Inbred F344
Valine / metabolism
Grant Support
Reg. No./Substance:

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