| Enhancement by food restriction of liver protein synthesis in the aging Fischer 344 rat. | |
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MedLine Citation:
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PMID: 3346519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related changes in liver protein synthesis of ad libitum fed and food-restricted SPF Fischer 344 rats have been measured. In ad libitum fed animals, valine incorporation increased from 3 to 6 mo of age, decreased to the 3-mo level at 12 mo, remained relatively constant through 18 mo, and then declined further at 24 mo of age. By 24 mo valine incorporation was 30% of the 6-mo value. Food restriction had no effect at 3 mo of age (6 wk of restriction) but at 6 mo the rate of valine incorporation was 35% greater than the control, an increment that was maintained throughout the life of the animal. Therefore, although food restriction does not prevent the age-related decline in protein synthesis, it does maintain the rate of liver valine incorporation at levels greater than those observed in the liver of the ad libitum fed animal. |
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Authors:
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W F Ward |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of gerontology Volume: 43 ISSN: 0022-1422 ISO Abbreviation: J Gerontol Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-04-18 Completed Date: 1988-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374762 Medline TA: J Gerontol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: B50-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, University of Texas Health Science Center, San Antonio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging* Animals Body Weight Diet* Liver / anatomy & histology, metabolism* Male Organ Size Protein Biosynthesis* Rats Rats, Inbred F344 Valine / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG01188/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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