Document Detail

Enhancement of bismuth toxicity by l-cysteine.
MedLine Citation:
PMID:  8680804     Owner:  NLM     Status:  MEDLINE    
Bismuth-induced encephalopathies observed in France about twenty years ago have never received convincing explanation. In previous papers we have shown in animal experiments that L-cysteine enhanced Bi absorption without leading to encephalopathies. in this paper we have studied in greater detail the toxicity and the pharmacokinetics of Bi, and L-cysteine, given by intraperitoneal route to mice, singly and simultaneously as a Bi-L-cysteine complex. Bismuth and L-cysteine, were nontoxic singly since their LD50 were higher than 15 mmol/kg, but were toxic (LD50 = 0.3 mmol/kg) when they were given as a complex. The complex was about 50 times more toxic than the separate products. The changes in the levels of Bi and L-cysteine in blood versus time after the injection of the Bi-L-cysteine complex suggests that the complex entered into the blood under a non-dissociated form but just afterwards the complex dissociated and the levels of Bi decreased rapidly whereas the levels of L-cysteine remained high. The concentrations of Bi in tissues, blood, brain, kidney and liver were higher when it was given as the Bi-L-cysteine complex than alone. But the increase of the levels of Bi in tissues induced by L-cysteine was not sufficient to explain the 50 fold increase of the toxicity of the complex in comparison with Bi and L-cysteine given alone. Since the increase of the levels of Bi induced by L-cysteine was not sufficient to explain the increase of the toxicity of the complex, another explanation is required. We suggest that this increase results from the stimulation of peroxidation by bismuth and L-cysteine, as already observed for iron and L-cysteine. Other experiments are needed to verify the validity of this hypothesis.
N Krari; Y Mauras; Allain
Related Documents :
18413404 - 203pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for mela...
23349454 - Differential effects of aging and exercise on intra-abdominal adipose arteriolar functi...
11299284 - Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse.
22878404 - Evaluation of left ventricular diastolic function after valve replacement in aortic ste...
12972864 - Exercise and diastolic function after myocardial infarction.
19017764 - Physical inactivity differentially alters dietary oleate and palmitate trafficking.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  89     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-08-20     Completed Date:  1996-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
Laboratoire de Pharmacologie, Centre Hospialier Universitaire, Angers Cedex, France
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bismuth / pharmacokinetics,  pharmacology,  toxicity*
Blood-Brain Barrier / drug effects
Cysteine / pharmacokinetics,  pharmacology*,  toxicity
Drug Combinations
Drug Synergism
Injections, Intraperitoneal
Lethal Dose 50
Lipid Peroxidation / drug effects
Tissue Distribution
Reg. No./Substance:
0/Drug Combinations; 52-90-4/Cysteine; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regio- and stereo-selective oxidation of phenylbutane by rat liver.
Next Document:  A possible non-aluminum oral phosphate binder? A comparative study on dietary phosphorus absorption.