| Enhancement of biliary phospholipid secretion by diethyl maleate administration in the rabbit. | |
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MedLine Citation:
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PMID: 3446199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of diethyl maleate administration on biliary phospholipid secretion was studied in male New Zealand rabbits. Bile flow was significantly enhanced during the first 40 min following i.p. injection of diethyl maleate at 3.2 mmol/kg body wt., after which it decreased progressively to values half those of the controls at 2 h of injection of the chemical. Bile acid secretion was not significantly modified during choleresis but was significantly reduced from 60 min of diethyl maleate administration onwards. A significant increase in biliary phospholipid secretion parallel to that occurring in bile flow was observed in diethyl maleate-treated rabbits. Our data confirm the uncoupling previously described for the rat between bile acid and phospholipid secretion into bile during diethyl maleate-induced choleresis. |
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Authors:
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J Gonzalez; R Jimenez; A Esteller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 46 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-05 Completed Date: 1988-05-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 713-7 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / drug effects*, secretion Bile Acids and Salts / secretion Cholagogues and Choleretics / pharmacology Male Maleates / pharmacology* Phospholipids / secretion* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholagogues and Choleretics; 0/Maleates; 0/Phospholipids; 141-05-9/diethyl maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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