| Enhancement of aromatic amino acid-nucleic acid base stacking interaction by metal coordination to base: fluorescence study on a tryptophan-Pt(II)-guanine ternary complex. | |
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MedLine Citation:
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PMID: 7656975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the effect of the Pt(II) ion on the stacking interaction between tryptophan and a guanine base, the quenching of Trp fluorescence was monitored for some systems in the absence and presence of the metal ion, and the association constants were obtained by the analysis of Eadie-Hofstee plots. All spectral data suggested that the stacking interaction is enhanced by the Pt(II) coordination to the guanine N7 atom. The result indicates the importance of the metal ion as a bookmark in the specific recognition of a nucleic acid base by an aromatic amino acid residue. |
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Authors:
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H Kawai; M Tarui; M Doi; T Ishida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 370 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-10-04 Completed Date: 1995-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 193-6 Citation Subset: IM |
Affiliation:
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Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Composition Fluorescence* Guanine / chemistry* Platinum / chemistry*, pharmacology* Platinum Compounds / pharmacology Purines / chemistry Tryptophan / chemistry*, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Platinum Compounds; 0/Purines; 120-73-0/purine; 73-22-3/Tryptophan; 73-40-5/Guanine; 7440-06-4/Platinum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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