| Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG. | |
| | |
MedLine Citation:
|
PMID: 23151945 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Targeted monoclonal antibodies (mAb) can be used therapeutically for tumors with identifiable antigens such as disialoganglioside GD2, expressed on neuroblastoma and melanoma tumors. Anti-GD2 mAbs (αGD2) can provide clinical benefit in patients with neuroblastoma. An important mechanism of mAb therapy is antibody-dependent cellular cytotoxicity (ADCC). Combinatorial therapeutic strategies can dramatically increase the anti-tumor response elicited by mAbs. We combined a novel αGD2 mAb, hu14.18K322A, with an immunostimulatory regimen of agonist CD40 mAb and class B CpG-ODN 1826 (CpG). Combination immunotherapy was more effective than the single therapeutic components in a syngeneic model of GD2-expressing B16 melanoma with minimal tumor burden. NK cell depletion in B6 mice showed that NK cells were required for the anti-tumor effect; however, anti-tumor responses were also observed in tumor-bearing SCID/beige mice. Thus, NK cell cytotoxicity did not appear to be essential. Peritoneal macrophages from anti-CD40 + CpG-treated mice inhibited tumor cells in vitro in an hu14.18K322A antibody-dependent manner. These data highlight the importance of myeloid cells as potential effectors in immunotherapy regimens utilizing tumor-specific mAb and suggest that further studies are needed to investigate the therapeutic potential of activated myeloid cells and their interaction with NK cells. |
| | |
Authors:
|
Kory L Alderson; Mitchell Luangrath; Megan M Elsenheimer; Stephen D Gillies; Fariba Navid; Alexander L Rakhmilevich; Paul M Sondel |
Related Documents
:
|
11091505 - Preoperative discrimination of fibroadenoma which is clinically and cytologically indis... 22949155 - Enhanced antitumoral activitiy of oncolytic herpes simplex virus with gemcitabine using... 23212295 - Intratumoral acetic acid injection eradicates human prostate cancer tumors in a murine ... 20685245 - Cytotoxic polyphenols against breast tumor cell in smilax china l. 21340755 - The molecular pathogenesis of ovarian cancer. 6508145 - Mansonella (e.) rotundicapita sp.n. and mansonella (e.) longicapita sp.n. (filarioidea ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-15 |
Journal Detail:
|
Title: Cancer immunology, immunotherapy : CII Volume: - ISSN: 1432-0851 ISO Abbreviation: Cancer Immunol. Immunother. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8605732 Medline TA: Cancer Immunol Immunother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA, kalderson@wisc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zoledronic acid-induced expansion of ?? T cells from early-stage breast cancer patients: effect of I...
Next Document: Guanosine protects against reperfusion injury in rat brains after ischemic stroke.