| Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides. | |
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MedLine Citation:
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PMID: 81494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragments of chopped lung from indomethacin treated guinea-pigs had an anti-aggregating effect when added to human platelet rich plasma (PRP), probably due to the production of prostacyclin (PGI2) since the effect was inhibited by 15-hydroperoxy arachidonic acid (15-HPAA, 10 micrograms ml(-1)). Both 15-HPAA (1-20 micrograms ml(-1) min (-1)) and 13-hydroperoxy linoleic acid (13-HPLA, 20 micrograms ml(-1) min(-1)) caused a marked enhancement of the anaphylactic release of histamine, slow-reacting substance of anaphylaxis (SRS-A) and rabbit aorta contracting substance (RCS) from guinea-pig isolated perfused lungs. This enhancement was not reversed by the concomitant infusion of either PGI2 (5 micrograms ml(-1) min (-1)) or 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha, 5 micrograms ml(-1) min(-1)). Anaphylactic release of histamine and SRS-A from guinea-pig perfused lungs was not inhibited by PGI2 (10 ng - 10 microgram ml(-1) min(-1)) but was inhibited by PGE2 (5 and 10 micrograms ml(-1) min (-1)). Antiserum raised to 5,6-dihydro prostacyclin (PGI1) in rabbits, which also binds PGI2, had no effect on the release of anaphylactic mediators. The fatty acid hydroperoxides may enhance mediator release either indirectly by augmenting thromboxane production or by a direct effect on sensitized cells. Further experiments to distinguish between these alternatives are described in the accompanying paper (27). |
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Authors:
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J J Adcock; L G Garland; S Moncada; J A Salmon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins Volume: 16 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1978 Aug |
Date Detail:
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Created Date: 1978-12-29 Completed Date: 1978-12-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-77 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis Animals Antigens Arachidonic Acids / pharmacology* Epoprostenol / biosynthesis, immunology, pharmacology Guinea Pigs Histamine Release / drug effects* Humans Immune Sera / pharmacology Indomethacin / pharmacology Linoleic Acids / pharmacology* Lung / drug effects*, metabolism Male Perfusion Platelet Aggregation / drug effects Prostaglandins E / pharmacology Prostaglandins F / pharmacology SRS-A / secretion* Thromboxane A2 / secretion |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Arachidonic Acids; 0/Immune Sera; 0/Linoleic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 0/SRS-A; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2 |
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