Document Detail

Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides.
MedLine Citation:
PMID:  81494     Owner:  NLM     Status:  MEDLINE    
Fragments of chopped lung from indomethacin treated guinea-pigs had an anti-aggregating effect when added to human platelet rich plasma (PRP), probably due to the production of prostacyclin (PGI2) since the effect was inhibited by 15-hydroperoxy arachidonic acid (15-HPAA, 10 micrograms ml(-1)). Both 15-HPAA (1-20 micrograms ml(-1) min (-1)) and 13-hydroperoxy linoleic acid (13-HPLA, 20 micrograms ml(-1) min(-1)) caused a marked enhancement of the anaphylactic release of histamine, slow-reacting substance of anaphylaxis (SRS-A) and rabbit aorta contracting substance (RCS) from guinea-pig isolated perfused lungs. This enhancement was not reversed by the concomitant infusion of either PGI2 (5 micrograms ml(-1) min (-1)) or 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha, 5 micrograms ml(-1) min(-1)). Anaphylactic release of histamine and SRS-A from guinea-pig perfused lungs was not inhibited by PGI2 (10 ng - 10 microgram ml(-1) min(-1)) but was inhibited by PGE2 (5 and 10 micrograms ml(-1) min (-1)). Antiserum raised to 5,6-dihydro prostacyclin (PGI1) in rabbits, which also binds PGI2, had no effect on the release of anaphylactic mediators. The fatty acid hydroperoxides may enhance mediator release either indirectly by augmenting thromboxane production or by a direct effect on sensitized cells. Further experiments to distinguish between these alternatives are described in the accompanying paper (27).
J J Adcock; L G Garland; S Moncada; J A Salmon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  16     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-77     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / pharmacology*
Epoprostenol / biosynthesis,  immunology,  pharmacology
Guinea Pigs
Histamine Release / drug effects*
Immune Sera / pharmacology
Indomethacin / pharmacology
Linoleic Acids / pharmacology*
Lung / drug effects*,  metabolism
Platelet Aggregation / drug effects
Prostaglandins E / pharmacology
Prostaglandins F / pharmacology
SRS-A / secretion*
Thromboxane A2 / secretion
Reg. No./Substance:
0/Antigens; 0/Arachidonic Acids; 0/Immune Sera; 0/Linoleic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 0/SRS-A; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2

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