Document Detail

Enhancement of allergic skin wheal responses and in vitro allergen-specific IgE production by computer-induced stress in patients with atopic dermatitis.
MedLine Citation:
PMID:  12676575     Owner:  NLM     Status:  MEDLINE    
Computer-induced stress enhanced allergen-specific skin wheal responses in patients with atopic dermatitis (AD) while it failed to do so in patients with allergic rhinitis (AR). Computer-induced stress also enhanced plasma levels of substance P (SP) and vasoactive intestinal peptide (VIP) in patients with AD, but not with AR. Peripheral blood mononuclear cells stimulated with combination of IL-4, IL-10, anti-CD40 mAb, and allergen produced allergen-specific IgE production in both patients with AD and AR. Computer-induced stress enhanced allergen-specific IgE production by peripheral blood mononuclear cells from patients with AD, but not from patients with AR. This is the first report that computer-induced stress enhances allergen-specific responses with concomitant increase of plasma levels of SP and VIP specifically in patients with AD. Since AD is often aggravated by stress, these finding may have implications for the pathophysiology and treatment of AD.
Hajime Kimata
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  17     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-04     Completed Date:  2003-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Kyoto Prefecture 611-0021, Uji-city, Japan.
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MeSH Terms
Dermatitis, Atopic / blood,  immunology*
Heart Rate
Histamine / metabolism
Immunoglobulin E / biosynthesis,  blood*
Leukocytes, Mononuclear / metabolism
Skin / immunology
Stress, Psychological / blood,  immunology*
Substance P / blood
Vasoactive Intestinal Peptide / blood
Reg. No./Substance:
33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 37341-29-0/Immunoglobulin E; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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