| Enhancement of allergic skin wheal responses and in vitro allergen-specific IgE production by computer-induced stress in patients with atopic dermatitis. | |
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MedLine Citation:
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PMID: 12676575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Computer-induced stress enhanced allergen-specific skin wheal responses in patients with atopic dermatitis (AD) while it failed to do so in patients with allergic rhinitis (AR). Computer-induced stress also enhanced plasma levels of substance P (SP) and vasoactive intestinal peptide (VIP) in patients with AD, but not with AR. Peripheral blood mononuclear cells stimulated with combination of IL-4, IL-10, anti-CD40 mAb, and allergen produced allergen-specific IgE production in both patients with AD and AR. Computer-induced stress enhanced allergen-specific IgE production by peripheral blood mononuclear cells from patients with AD, but not from patients with AR. This is the first report that computer-induced stress enhances allergen-specific responses with concomitant increase of plasma levels of SP and VIP specifically in patients with AD. Since AD is often aggravated by stress, these finding may have implications for the pathophysiology and treatment of AD. |
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Authors:
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Hajime Kimata |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 17 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-04 Completed Date: 2003-05-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
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Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Kyoto Prefecture 611-0021, Uji-city, Japan. unitikah@m12.alpha-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Computers Dermatitis, Atopic / blood, immunology* Female Heart Rate Histamine / metabolism Humans Immunoglobulin E / biosynthesis, blood* Leukocytes, Mononuclear / metabolism Male Skin / immunology Stress, Psychological / blood, immunology* Substance P / blood Vasoactive Intestinal Peptide / blood |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 37341-29-0/Immunoglobulin E; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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