| Enhancement of Muramyldipeptide (MDP) Immunostimulatory Activity by Controlled Multimerization on Dendrimers. | |
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MedLine Citation:
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PMID: 22052563 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Peptidoglycan is a widespread bacterial PAMP molecule and a powerful initiator of innate immune responses. It consists of repeating units of MDP, which as a monomer is only weakly immunostimulatory. Here, MDP-coupled dendrimers were prepared and investigated for stimulation of pig blood mononuclear cells. Compared to monomeric MDP, MDP-dendrimers induced a markedly enhanced production of IL-12 p40, IL-1β and IL-6 and completely down-regulated surface expression of B7 and MHC class II. These results suggest a possible novel strategy based on controlled multimerization of minimal PAMP motifs on dendrimers for preparing molecularly defined immunostimulators with predictable bioactivities. |
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Authors:
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Nanna S Sorensen; Ulrik Boas; Peter M H Heegaard |
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Publication Detail:
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Type: Journal Article Date: 2011-08-25 |
Journal Detail:
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Title: Macromolecular bioscience Volume: 11 ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 1484-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Innate Immunology Group, National Veterinary Institute, Technical University of Denmark, Bülowsvej 27, 1790 Copenhagen V, Denmark. nsor@vet.dtu.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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