| Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin. | |
| | |
MedLine Citation:
|
PMID: 22112759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Many approaches have shown beneficial effects of modified mesenchymal stem cells (MSCs) for treatment of infarcted myocardium, but have primarily focused on enhancing the survival of transplanted MSCs. Here, we show the dual benefits of periostin-overexpressing MSCs (p-MSCs) for infarcted myocardium. P-MSCs led to the marked histological and functional recovery of infarcted myocardium by enhancing survival of MSCs and directly preventing apoptosis of cardiomyocytes. Survival of p-MSCs themselves and cardiomyocytes co-cultured with p-MSCs or treated with the conditioned media from p-MSCs was significantly increased under hypoxic conditions. Decreases in adhesion-related integrins were reversed in cardiomyocytes co-cultured with p-MSCs, followed by increases in p-PI3K and Akt, indicating that periostin activates the PI3K pathway through adhesion-related integrins. When p-MSCs were injected into myocardial infarcted rats, histological pathology and cardiac function were significantly improved compared to MSC-injected controls. Thus, periostin might be a new target of therapeutic treatments using MSCs as carriers for infarcted myocardium. |
| | |
Authors:
|
Yun-Hyeong Cho; Min-Ji Cha; Byeong-Wook Song; Il-Kwon Kim; Heesang Song; Woochul Chang; Soyeon Lim; Onju Ham; Se-Yeon Lee; Eunmi Choi; Hyuck Moon Kwon; Ki-Chul Hwang |
Related Documents
:
|
816189 - Regional and global myocardial effects of intravenous and sublingual nitroglycerin trea... 16302449 - Effects of total coronary artery occlusion on vascular endothieial growth factor and tr... 21963909 - Angiotensin iv protects against angiotensin ii-induced cardiac injury via at4 receptor. 7326689 - Haemodynamic and metabolic effects of the antiarrhythmic drug melperone during acute le... 6859279 - A nonsurgical canine model of chronic left ventricular myocardial dysfunction. 3633749 - Effect of hydrocortisone on the hemodynamics and serum ck and mbck enzymes in acute myo... 19254829 - Statins for post resuscitation syndrome. 1257939 - Elective operations for post-infarction left ventricular aneurysms. 3335689 - Time course of left ventricular dilation after myocardial infarction: influence of infa... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
|
Title: Biomaterials Volume: - ISSN: 1878-5905 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Cardiology Division, Myongji Hospital, Kwandong University College of Medicine, Hwajeongdong, Deokyanggu, Goyangsi, Gyeonggido 412-270, Republic of Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli ...
Next Document: A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanopa...