Document Detail


Enhancement of Fatty Acid-based Polyurethanes Cytocompatibility by Non-covalent Anchoring of Chondroitin Sulfate.
MedLine Citation:
PMID:  23077104     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
For tissue engineering purpose biopolymer chondroitin sulfate (CS), one of the major components of cartilage and bone extracellular matrix, was immobilized onto the surface of amino-functionalized polyurethane (PU) films derived from naturally occurring oleic and 10-undecenoic acids. The amino-functionalized PUs were prepared by aminolysis with 1,6-hexamethylenediamine of synthesized PUs containing methyl ester groups. FTIR-ATR, XPS, SEM, and water contact angle measurements were used to confirm the surface changes at each step of treatment, both in morphologies and chemical composition. Cytotoxicity and cell morphology analysis using osteoblast cell line MG63 showed that PU-CS films are suitable materials for cell growth, spreading, and differentiation.
Authors:
Rodolfo J González-Paz; Gerard Lligadas; Juan C Ronda; Marina Galià; Ana M Ferreira; Francesca Boccafoschi; Gianluca Ciardelli; Virginia Cádiz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-17
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  Macromol Biosci     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Analytical and Organic Chemistry, Rovira i Virgili University, Campus Sescelades, C/Marcel.lí Domingo s/n, 43007 Tarragona, Spain.
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