Document Detail

Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine model.
MedLine Citation:
PMID:  23261435     Owner:  NLM     Status:  Publisher    
Recent advances in neuroscience and immunology have revealed a bidirectional interaction between the nervous and immune systems. Therefore, the gastrointestinal tract may be modulated by neuro-immune interactions, but little information about this interaction is available. Intrinsic and extrinsic primary afferent neurons play an important role in this interaction because of their abilities to sense, process and transmit various information in the intestinal microenvironment. Calcitonin gene-related peptide (CGRP) is exclusively contained in intrinsic and extrinsic primary afferent neurons in the mouse intestine. Therefore, we investigated CGRP-immunoreactive nerve fibers in the colonic mucosa of mice induced to develop food allergy. CGRP-immunoreactive nerve fibers were specifically increased with the development of food allergy, and the fibers were juxtaposed to mucosal mast cells in the colonic mucosa of food allergy mice. Denervation of the extrinsic afferent neurons using neonatal capsaicin treatment did not affect the development of food allergy or the density and distribution of CGRP-immunoreactive nerve fibers in the colonic mucosa of food allergy mice. Furthermore, the mRNA and plasma level of CGRP was increased in food allergy mice. These results suggest that the activation of intrinsic primary afferent neurons in the intestine contributes to the development and pathology of food allergy.
Jaemin Lee; Takeshi Yamamoto; Shusaku Hayashi; Hirofumi Kuramoto; Makoto Kadowaki
Related Documents :
2192555 - Acute diarrhea associated with travel.
23609775 - Fiber and prebiotics: mechanisms and health benefits.
8219345 - Epidemiological aspects of outbreaks of food-borne salmonellosis in scotland between 19...
24140465 - Polycyclic aromatic hydrocarbons in food - efflux of the conjugated biomarker 1-hydroxy...
20472105 - The costly benefits of opposing agricultural biotechnology.
22245255 - Neurochemical and behavioral analyses of the lateral hypothalamic syndrome: a look back.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  -     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy.
Next Document:  Novel female-specific trans-spliced and alternative-splice forms of dsx in the silkworm Bombyx mori.