Document Detail


Enhanced vasomotion of cerebral arterioles in spontaneously hypertensive rats.
MedLine Citation:
PMID:  2352485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrinsic rhythmic changes in the diameter of pial cerebral arterioles (30-70 microns) in anesthetized normotensive and hypertensive rats were assessed in vivo to determine if any significant differences exist between the two strains. All diameter measurements were analyzed using a traditional graphic analysis technique and a new frequency spectrum analysis technique known as the Prony Spectral Line Estimator. Graphic analysis of the data revealed that spontaneously hypertensive rats (SHR) possess a significantly greater fundamental frequency (5.57 +/- 0.28 cycles/min) of vasomotion compared to the control Wistar-Kyoto normotensive rats (WKY) (1.95 +/- 0.37 cycles/min). Furthermore, the SHR cerebral arterioles exhibited a significantly greater amplitude of vasomotion (10.07 +/- 0.70 microns) when compared to the WKY cerebral arterioles of the same diameter (8.10 +/- 0.70 microns). Diameter measurements processed with the Prony technique revealed that the fundamental frequency of vasomotion in SHR cerebral arterioles (6.14 +/- 0.39 cycles/min) was also significantly greater than that of the WKY cerebral arterioles (2.99 +/- 0.42 cycles/min). The mean amplitudes of vasomotion in the SHR and WKY strains obtained by the Prony analysis were found not to be statistically significant in contrast to the graphic analysis of the vasomotion amplitude of the arterioles. In addition, the Prony system was able to consistently uncover a very low frequency of vasomotion in both strains of rats that was typically less than 1 cycle/min and was not significantly different between the two strains. The amplitude of this slow frequency was also not significantly different between the two strains. The amplitude of the slow frequency of vasomotion (less than 1 cycle/min) was not different from the amplitude of the higher frequency (2-6 cycles/min) vasomotion by Prony or graphic analysis. These data suggest that a fundamental intrinsic defect exists in the spontaneously hypertensive rat that may contribute to the pathogenesis of hypertension in these animals.
Authors:
D J Lefer; C D Lynch; K C Lapinski; P M Hutchins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Microvascular research     Volume:  39     ISSN:  0026-2862     ISO Abbreviation:  Microvasc. Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-07-17     Completed Date:  1990-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-39     Citation Subset:  IM; S    
Affiliation:
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27103.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / pathology,  physiopathology
Cerebrovascular Circulation / physiology*
Hypertension / etiology,  pathology,  physiopathology*
Male
Periodicity
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Vasoconstriction / physiology*
Vasodilation / physiology
Grant Support
ID/Acronym/Agency:
HL 13936-16/HL/NHLBI NIH HHS
Investigator
Investigator/Affiliation:
P M Hutchins / Wake Forest U, Winston-Salem, NC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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