Document Detail


Enhanced vasoconstriction and reduced vasorelaxation induced by testosterone and nandrolone in hypercholesterolemic rabbits.
MedLine Citation:
PMID:  15225667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Androgenic-anabolic steroids (AAS) are widely abused by athletes and this abuse has been associated with many serious circulatory events including sudden cardiac death, myocardial infarction and cardiac hypertrophy. The effect of chronic treatment for 16 weeks with testosterone (25mg(-1)kg(-1)week(-1)) and nandrolone (50mg(-1)kg(-1)week(-1)) on serum lipids of male hypercholesterolemic New Zealand rabbits was investigated. The responses of isolated rabbit aortic rings to some vasoconstrictors (epinephrine, serotonin and endothelin-1) and vasodilators (adenosine and sodium nitroprusside) were also measured after treatment. Testosterone and nandrolone significantly reduced HDL-cholesterol levels, potentiated vasoconstriction responses to epinephrine, serotonin and endothelin-1, and attenuated vasorelaxant responses to sodium nitroprusside in rabbits. Nandrolone also caused a significant increase in LDL-cholesterol levels. No significant changes in adenosine relaxation were found in rabbits. The results of the present study showed that the abuse of AAS in presence of hypercholesterolemia can enhance atherogenicity and vasospasm as well as attenuation of vasorelaxation. Therefore the abuse of AAS is harmful to the vascular system and should be prohibited.
Authors:
E M Ammar; Shehta A Said; Mohammed S Hassan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  50     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. emammar@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Hypercholesterolemia / blood*
Male
Nandrolone / pharmacology*,  toxicity
Rabbits
Substance-Related Disorders
Testosterone / pharmacology*,  toxicity
Vasoconstriction / drug effects*,  physiology
Vasodilation / drug effects*,  physiology
Chemical
Reg. No./Substance:
434-22-0/Nandrolone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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