| Enhanced vagal activity and normal arginine vasopressin response in carotid sinus syndrome: implications for a central abnormality in carotid sinus hypersensitivity. | |
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MedLine Citation:
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PMID: 3677144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relation between arginine vasopressin and vagal activity in carotid sinus syndrome was studied in 10 patients and 17 age matched controls using head up tilt as a stimulus. Of the controls, seven had unexplained syncope and 10 were healthy elderly subjects with no previous history of syncope. Subjects were studied supine for 45 min and thereafter during 120 min head up tilt to 40 degrees. Phasic arterial pressure and heart rate were monitored throughout. Serum was sampled at frequent intervals to measure arginine vasopressin, noradrenaline, and adrenaline concentrations. Seventy per cent of carotid sinus patients had vasovagal syncope at (mean(SD)) 25(4) min after tilt compared with 43% of subjects with unexplained syncope and one healthy elderly control. The maximum (mean(SD)) fall in systolic blood pressure and heart rate was 70(20) mmHg and 20(7) beats.min-1 (p less than 0.001 and p less than 0.01 respectively). Arginine vasopressin, noradrenaline, and adrenaline concentrations rose significantly in syncopal subjects (p less than 0.001, p less than 0.01, and p less than 0.05 respectively). Changes in systolic blood pressure, heart rate, and hormone concentrations were similar for patients with carotid sinus syndrome and control subjects. For those who completed the tilt period without the development of symptoms, systolic blood pressure and arginine vasopressin and adrenaline concentrations were unchanged, whereas noradrenaline concentrations and heart rate rose significantly. Vasovagal activity is thus appreciably increased in carotid sinus syndrome. Furthermore, the afferent limb of the carotid sinus reflex appears to be intact in patients with carotid sinus syndrome since the pattern of arginine vasopressin release was not different from controls.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R A Kenny; C C Lyon; A M Ingram; J Bayliss; S L Lightman; R Sutton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 21 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1988-01-20 Completed Date: 1988-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 545-50 Citation Subset: IM; S |
Affiliation:
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Cardiac Department, Westminster Hospital, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arginine Vasopressin / blood* Blood Pressure Carotid Sinus / physiopathology* Female Heart Rate Humans Male Middle Aged Posture Reflex, Abnormal / blood, etiology, physiopathology* Syncope / blood, etiology, physiopathology* Syndrome Vagus Nerve / physiopathology* |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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