Document Detail


Enhanced ultrafiltration using 7.5% icodextrin/1.36% glucose combination dialysate: a pilot study.
MedLine Citation:
PMID:  15559483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A pilot study to compare the use of a combination dialysate (7.5% icodextrin/1.36% glucose) versus icodextrin 7.5% alone for the long dwell in patients on peritoneal dialysis (PD). DESIGN: A 4-week, prospective, randomized crossover study. SETTING: A large regional renal unit providing treatment for a population of 1.7 million. PATIENTS: Five patients on continuous ambulatory PD (CAPD) and 3 patients on automated PD. MAIN OUTCOME MEASUREMENTS: Long-dwell and 24-hour ultrafiltration volumes, body weight, 24-hour ambulatory blood pressure, and antihypertensive/diuretic tablet count. RESULTS: The use of the combination dialysate resulted in an increase in the median (interquartile range) long-dwell ultrafiltration, from 750 (650-828) mL to 1000 (889-1100) mL (p < 0.001), and 24-hour ultrafiltration, from 739 (400-1623) mL to 956 (700-1750) mL (p < 0.001). Weight, blood pressure, and tablet count remained unchanged. CONCLUSIONS: The use of the novel combination dialysate resulted in a 33% increase in long-dwell ultrafiltration and a 29% increase in 24-hour ultrafiltration.
Authors:
Fiona Dallas; Sarah B Jenkins; Martin E Wilkie
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  24     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2004-11-22     Completed Date:  2005-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  542-6     Citation Subset:  IM    
Affiliation:
Sheffield Kidney Institute, Sheffield, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Over Studies
Dialysis Solutions* / administration & dosage,  chemistry
Female
Glucans / administration & dosage*
Glucose / administration & dosage*
Humans
Male
Middle Aged
Peritoneal Dialysis*
Peritoneal Dialysis, Continuous Ambulatory*
Pilot Projects
Prospective Studies
Time Factors
Ultrafiltration
Chemical
Reg. No./Substance:
0/Dialysis Solutions; 0/Glucans; 0/icodextrin; 50-99-7/Glucose
Comments/Corrections
Comment In:
Perit Dial Int. 2004 Nov-Dec;24(6):501-3   [PMID:  15559472 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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