Document Detail

Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly.
MedLine Citation:
PMID:  25369176     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Meal duration may influence cardiometabolic health. The aim of this study was to explore postprandial effects of meal duration on human metabolism and appetite.
DESIGN: Postprandial comparisons following a standard meal eaten slowly over 40-minutes ('D40') and the same meal eaten quickly over 10-minutes ('D10') on a different day. Each participant therefore acted as their own control, thereby limiting confounding factors.
PATIENTS: Obese pre-menopausal Caucasian women (n=10) with confirmed normoglycaemia were recruited from an Obesity clinic at UHCW, Coventry UK. Subjects underwent whole-body calorimetry (8-hours) on two separate days.
MEASUREMENTS: Following standard lunch (D40 vs D10), 4-hour postprandial analysis included thermic effect of food (TEF) and bloods taken at pre-defined times (including baseline fasting). Analytes included lipid-profile, adiponectin, insulin, glucose, ghrelin, leptin, endotoxin, gut and pancreatic hormones. Appetite was measured using visual-analogue scales and ad libitum food intake at subsequent meal. Paired-sample t-tests (including area under the curve [AUC]) were used to compare D40 and D10 trials.
RESULTS: Postprandial TEF (over 240-minutes) was significantly greater for D40 than D10 (mean [SEM]: 80.9Kcal [3.8] versus 29.9Kcal [3.4]; 10.6% versus 3.9% respectively, P=0.006; AUC versus respectively, P=0.02). Postprandial plasma NEFA was significantly lower and adiponectin levels were significantly higher for D40 than D10 (AUC [SEM]: NEFA 627μ [56] vs 769μ [60] respectively, P=0.02; adiponectin 33.4μ [3.9] vs 27.3μ [3.8] respectively, P=0.04). Other postprandial analytes and appetite measures were equivalent.
CONCLUSIONS: In obese women, eating slowly associates with enhanced TEF, elevated serum adiponectin and suppressed NEFA. This article is protected by copyright. All rights reserved.
Narendra L Reddy; Cheng J Peng; Marcos C Carreira; Louise Halder; John Hattersley; Milan K Piya; Gyanendra Tripathi; Harpal S Randeva; Felipe F Casanueva; Philip G McTernan; Sudhesh Kumar; Thomas M Barber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-4
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-4     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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