Document Detail

Enhanced sympathetic nervous activity after intravenous propranolol in ischaemic heart disease: plasma noradrenaline splanchnic blood flow and mixed venous oxygen saturation at rest and during exercise.
MedLine Citation:
PMID:  417929     Owner:  NLM     Status:  MEDLINE    
To study the mechanisms by which acute beta-adrenergic blockade may change the activity of the sympathetic nervous system we have measured haemodynamic responses including splanchnic blood flow in twenty-three patients with ischaemic heart disease at rest and during supine exercise before and after i.v. injection of 0.039 mmol (10 mg) dl-propranolol. After propranolol both at rest and on exercise blood pressure, cardiac output and heart rate decreased, while splanchnic vascular resistance increased; mixed venous oxygen saturation decreased whilst arterial oxygen saturation and oxygen uptake were unchanged. Plasma noradrenaline increased after propranolol, values correlating with mixed venous oxygen saturation and splanchnic vascular resistance, both at rest and during exercise before and after propranolol, only at rest was there any correlation with arterial blood pressure. The increase in sympathetic nervous activity after propranolol may be due to a reduction in cardiac output and thereby alteration of the metabolic state (oxygen or related factors) in tissues. Afferent neural signals from the tissues may play a significant role in the regulation of sympathetic nervous activity.
J F Hansen; B Hesse; N J Christensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  8     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM; S    
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MeSH Terms
Abdomen / blood supply
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / blood,  physiopathology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Norepinephrine / blood*
Oxygen / blood*
Physical Exertion
Propranolol / pharmacology*
Regional Blood Flow / drug effects
Sympathetic Nervous System / drug effects*
Vascular Resistance / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 525-66-6/Propranolol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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