Document Detail

Enhanced sympathetic nervous activity after intravenous propranolol in ischaemic heart disease: plasma noradrenaline splanchnic blood flow and mixed venous oxygen saturation at rest and during exercise.
MedLine Citation:
PMID:  417929     Owner:  NLM     Status:  MEDLINE    
To study the mechanisms by which acute beta-adrenergic blockade may change the activity of the sympathetic nervous system we have measured haemodynamic responses including splanchnic blood flow in twenty-three patients with ischaemic heart disease at rest and during supine exercise before and after i.v. injection of 0.039 mmol (10 mg) dl-propranolol. After propranolol both at rest and on exercise blood pressure, cardiac output and heart rate decreased, while splanchnic vascular resistance increased; mixed venous oxygen saturation decreased whilst arterial oxygen saturation and oxygen uptake were unchanged. Plasma noradrenaline increased after propranolol, values correlating with mixed venous oxygen saturation and splanchnic vascular resistance, both at rest and during exercise before and after propranolol, only at rest was there any correlation with arterial blood pressure. The increase in sympathetic nervous activity after propranolol may be due to a reduction in cardiac output and thereby alteration of the metabolic state (oxygen or related factors) in tissues. Afferent neural signals from the tissues may play a significant role in the regulation of sympathetic nervous activity.
J F Hansen; B Hesse; N J Christensen
Related Documents :
131139 - The effect of thymoxamine and cromolyn sodium on postexercise bronchoconstriction in as...
21673489 - Exercise in the management of type 2 diabetes mellitus: what are the benefits and how d...
3296089 - Calcium antagonists and exercise performance.
17023229 - Development of a pharmacokinetic/pharmacodynamic model for carvedilol to predict beta1-...
2551129 - Density and functioning of human lymphocytic beta-adrenergic receptors during prolonged...
233499 - Differential beta-adrenergic sensitivity of atrial tissue assessed by chronotropic and ...
15292739 - Effects of oat beta-glucan on innate immunity and infection after exercise stress.
21836049 - Exercise-induced adaptations of cardiac redox homeostasis and remodeling in heterozygou...
2355209 - Effect of variation in form on the cost of terrestrial locomotion.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  8     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abdomen / blood supply
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / blood,  physiopathology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Norepinephrine / blood*
Oxygen / blood*
Physical Exertion
Propranolol / pharmacology*
Regional Blood Flow / drug effects
Sympathetic Nervous System / drug effects*
Vascular Resistance / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 525-66-6/Propranolol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of hepatic demethylation of aminopyrine by oral contraceptive steroids in humans.
Next Document:  Serum prolactin levels in eighty patients with sarcoidosis.