| Enhanced sympathetic nervous activity after intravenous propranolol in ischaemic heart disease: plasma noradrenaline splanchnic blood flow and mixed venous oxygen saturation at rest and during exercise. | |
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MedLine Citation:
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PMID: 417929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the mechanisms by which acute beta-adrenergic blockade may change the activity of the sympathetic nervous system we have measured haemodynamic responses including splanchnic blood flow in twenty-three patients with ischaemic heart disease at rest and during supine exercise before and after i.v. injection of 0.039 mmol (10 mg) dl-propranolol. After propranolol both at rest and on exercise blood pressure, cardiac output and heart rate decreased, while splanchnic vascular resistance increased; mixed venous oxygen saturation decreased whilst arterial oxygen saturation and oxygen uptake were unchanged. Plasma noradrenaline increased after propranolol, values correlating with mixed venous oxygen saturation and splanchnic vascular resistance, both at rest and during exercise before and after propranolol, only at rest was there any correlation with arterial blood pressure. The increase in sympathetic nervous activity after propranolol may be due to a reduction in cardiac output and thereby alteration of the metabolic state (oxygen or related factors) in tissues. Afferent neural signals from the tissues may play a significant role in the regulation of sympathetic nervous activity. |
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Authors:
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J F Hansen; B Hesse; N J Christensen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 8 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-07-24 Completed Date: 1978-07-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 31-6 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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blood supply Adult Aged Blood Pressure / drug effects Cardiac Output / drug effects Coronary Disease / blood, physiopathology* Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Middle Aged Norepinephrine / blood* Oxygen / blood* Physical Exertion Propranolol / pharmacology* Regional Blood Flow / drug effects Sympathetic Nervous System / drug effects* Vascular Resistance / drug effects Veins |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 525-66-6/Propranolol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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