Document Detail

Enhanced streptokinase-induced thrombolysis using heparin in a rabbit model.
MedLine Citation:
PMID:  2488007     Owner:  NLM     Status:  MEDLINE    
Heparin potentiation of clot lysis by streptokinase was studied in a rabbit model. Clot was initiated in the rabbit aorta with stasis and thrombin and allowed to naturally propagate proximally until stasis met flow. The clot was allowed to age for 1 h before assigning treatment. Fifteen rabbits (group I) were given streptokinase (10,000 IU/h) and 11 rabbits (group II) were given streptokinase (10,000 IU/h) plus sodium-heparin (120 IU/h). Thrombolytic therapy was continued for 5 h. Clot lysis averaged 30% in group I and 70% in group II. Ten of 11 rabbits in group II had more than 50% clot lysis, whereas only 4 of 15 in group I had this degree of lysis. One group II rabbit and four group I rabbits died prematurely; each was noted to have clot propagation at the time of death. While a trend for amelioration of hypofibrinogenemia was observed in the group receiving both streptokinase and heparin, this difference was not statistically significant. We conclude, in the animal model, that thrombolysis by a combination of heparin and streptokinase is more effective than streptokinase alone. Systemic effects are apparently no worse with the combination.
R L Kolts; H S Maki; M E Kuehner; R C Roberts; R D Sautter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  2     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:  1989  
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Department of Surgery, Marshfield Clinic, WI 54449.
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MeSH Terms
Aortic Diseases / drug therapy*
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Fibrinolysis / drug effects
Heparin / administration & dosage,  pharmacology,  therapeutic use*
Streptokinase / administration & dosage,  pharmacology,  therapeutic use*
Thrombolytic Therapy*
Thrombosis / drug therapy*
Reg. No./Substance:
9005-49-6/Heparin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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