Document Detail


Enhanced streptokinase-induced thrombolysis using heparin in a rabbit model.
MedLine Citation:
PMID:  2488007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heparin potentiation of clot lysis by streptokinase was studied in a rabbit model. Clot was initiated in the rabbit aorta with stasis and thrombin and allowed to naturally propagate proximally until stasis met flow. The clot was allowed to age for 1 h before assigning treatment. Fifteen rabbits (group I) were given streptokinase (10,000 IU/h) and 11 rabbits (group II) were given streptokinase (10,000 IU/h) plus sodium-heparin (120 IU/h). Thrombolytic therapy was continued for 5 h. Clot lysis averaged 30% in group I and 70% in group II. Ten of 11 rabbits in group II had more than 50% clot lysis, whereas only 4 of 15 in group I had this degree of lysis. One group II rabbit and four group I rabbits died prematurely; each was noted to have clot propagation at the time of death. While a trend for amelioration of hypofibrinogenemia was observed in the group receiving both streptokinase and heparin, this difference was not statistically significant. We conclude, in the animal model, that thrombolysis by a combination of heparin and streptokinase is more effective than streptokinase alone. Systemic effects are apparently no worse with the combination.
Authors:
R L Kolts; H S Maki; M E Kuehner; R C Roberts; R D Sautter
Related Documents :
19527967 - Hydroxyethyl starch interferes with human blood ex vivo coagulation, platelet function ...
24389597 - Pharmacodynamic comparison of pitavastatin versus atorvastatin on platelet reactivity i...
15120537 - Inference revision processing in adults with and without aphasia.
8306677 - Plasma degradation of platelet-activating factor in severely ill patients with clinical...
2118477 - Arachidonic acid metabolism in heat-shock treated human leucocytes.
1652137 - Effects of tenoxicam on superoxide anion formation, beta-glucuronidase release and fmlp...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  2     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:  1989  
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, Marshfield Clinic, WI 54449.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Diseases / drug therapy*
Disease Models, Animal
Drug Synergism
Drug Therapy, Combination
Fibrinolysis / drug effects
Heparin / administration & dosage,  pharmacology,  therapeutic use*
Rabbits
Streptokinase / administration & dosage,  pharmacology,  therapeutic use*
Thrombolytic Therapy*
Thrombosis / drug therapy*
Chemical
Reg. No./Substance:
9005-49-6/Heparin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of copovithane as a nonspecific immunomodulator in surgically simulated sepsis.
Next Document:  Role of extrinsic and intrinsic nerves in hormonal induction of the migrating motor complex in the j...