| Enhanced streptokinase-induced thrombolysis using heparin in a rabbit model. | |
MedLine Citation:
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PMID: 2488007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin potentiation of clot lysis by streptokinase was studied in a rabbit model. Clot was initiated in the rabbit aorta with stasis and thrombin and allowed to naturally propagate proximally until stasis met flow. The clot was allowed to age for 1 h before assigning treatment. Fifteen rabbits (group I) were given streptokinase (10,000 IU/h) and 11 rabbits (group II) were given streptokinase (10,000 IU/h) plus sodium-heparin (120 IU/h). Thrombolytic therapy was continued for 5 h. Clot lysis averaged 30% in group I and 70% in group II. Ten of 11 rabbits in group II had more than 50% clot lysis, whereas only 4 of 15 in group I had this degree of lysis. One group II rabbit and four group I rabbits died prematurely; each was noted to have clot propagation at the time of death. While a trend for amelioration of hypofibrinogenemia was observed in the group receiving both streptokinase and heparin, this difference was not statistically significant. We conclude, in the animal model, that thrombolysis by a combination of heparin and streptokinase is more effective than streptokinase alone. Systemic effects are apparently no worse with the combination. |
Authors:
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R L Kolts; H S Maki; M E Kuehner; R C Roberts; R D Sautter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of investigative surgery : the official journal of the Academy of Surgical Research Volume: 2 ISSN: 0894-1939 ISO Abbreviation: J Invest Surg Publication Date: 1989 |
Date Detail:
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Created Date: 1991-04-18 Completed Date: 1991-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809255 Medline TA: J Invest Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 431-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Marshfield Clinic, WI 54449. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Diseases / drug therapy* Disease Models, Animal Drug Synergism Drug Therapy, Combination Fibrinolysis / drug effects Heparin / administration & dosage, pharmacology, therapeutic use* Rabbits Streptokinase / administration & dosage, pharmacology, therapeutic use* Thrombolytic Therapy* Thrombosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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