Document Detail


Enhanced skin permeation and hydration by magnetic field array: preliminary in-vitro and in-vivo assessment.
MedLine Citation:
PMID:  20636856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of the study was determine the effect of magnetic film array technology on the skin permeation of urea.
METHODS: A 5% urea gel was applied to human epidermal membrane in vitro and human skin in vivo. Application of gel with magnetic film array and plastic occlusive film was compared with application of gel with a plastic occlusive film and non-magnetic film. In-vitro epidermal penetration was determined using a Franz-type diffusion system. In-vivo permeation and changes in epidermal properties were visualised by optical coherence tomography.
KEY FINDINGS: The mean cumulative permeation of urea over 2 h for magnetic film array application was 89.54 +/- 7.34 microg/cm(2) as compared with 20.83 +/- 2.02 microg/cm(2) for passive occluded application (mean +/- SEM, n = 9/8), representing greater than 4-fold increase over the 2-h application time period. Administration of urea with the magnetic film array resulted in the lag time being reduced from 40.58 +/- 3.98 to 21.13 +/- 6.27 min (P < 0.02), while steady state flux increased from 0.24 +/- 0.03 to 0.75 +/- 0.06 microg/cm(2) per min (P < 0.0001). Under active occlusion, the relative change in epidermal thickness as determined by optical coherence tomography increased by 16 and 11% at 30 and 60 min, respectively.
CONCLUSIONS: Administration with a novel magnetic film array technology provided enhanced skin penetration of urea and increased epidermal hydration when compared with administration under an occlusive film only.
Authors:
Heather A E Benson; Gayathri Krishnan; Jeffrey Edwards; Yih Miin Liew; Vincent P Wallace
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  62     ISSN:  2042-7158     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-26     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-701     Citation Subset:  IM    
Affiliation:
Curtin Health Innovation Research Institute, School of Pharmacy, Curtin University, Australia. h.benson@curtin.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Gels
Humans
Magnetics*
Male
Middle Aged
Permeability
Skin / metabolism
Skin Absorption*
Tomography, Optical Coherence
Urea / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Gels; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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