Document Detail


Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive-compulsive disorder.
MedLine Citation:
PMID:  23043789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The underlying neurobiology of addictive or repetitive behaviours, such as obsessive-compulsive disorder (OCD), involves dopaminergic dysregulation. While addictive behaviour depends strongly on mesolimbocortical dopaminergic responses, repetitive behaviours have been associated with dopaminergic dysregulation in the basal ganglia-thalamo-cortical circuitry. The present study investigates differences in brain stimulation reward in rats with quinpirole-induced compulsive checking behaviour, in order to examine if deficits in reward processing are also relevant for OCD. Rats were tested in the intracranial self-stimulation (ICSS) paradigm, which targets reward-related responses. After phenotype induction, animals were implanted with a monopolar stimulation electrode in the left medial forebrain bundle and trained to press a lever to self-administer electric stimulation of varying frequency. The curve-shift method was used to assess the reward-facilitating effects of d-amphetamine and the reward-attenuating effects of haloperidol (a D(2) antagonist). Thresholds for ICSS were estimated before and after drug/saline injection. The reward-facilitating effects of d-amphetamine were enhanced in quinpirole-treated rats in comparison to controls. This finding suggests that chronic quinpirole-treatment induces changes within the reward circuitry relevant for compulsive behaviour in the rat.
Authors:
Timo T Schmidt; Ellis Rea; Julia Shababi-Klein; George Panagis; Christine Winter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  16     ISSN:  1469-5111     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2014-01-03     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1083-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Central Nervous System Stimulants / therapeutic use*
Conditioning, Operant / drug effects
Dextroamphetamine / administration & dosage*
Disease Models, Animal
Dopamine Antagonists / pharmacology
Electric Stimulation / adverse effects
Haloperidol / pharmacology
Male
Obsessive-Compulsive Disorder / chemically induced*,  drug therapy*,  psychology
Quinpirole / toxicity*
Rats
Rats, Wistar
Reward*
Self Administration
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Dopamine Antagonists; 20OP60125T/Quinpirole; J6292F8L3D/Haloperidol; TZ47U051FI/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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