| Enhanced resting activity of the oral somatosensory cortex in obese subjects. | |
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MedLine Citation:
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PMID: 12151759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cerebral mechanisms underlying excess food intake in obese subjects are poorly understood. We used PET and 2-deoxy-2[18F]fluoro-D-glucose to assess differences in regional brain metabolism between obese and lean subjects at rest. Brain metabolic images were analyzed using statistical parameter maps. We found that obese subjects have significantly higher metabolic activity in the bilateral parietal somatosensory cortex in the regions where sensation to the mouth, lips and tongue are located. The enhanced activity in somatosensory regions involved with sensory processing of food in the obese subjects could make them more sensitive to the rewarding properties of food related to palatability and could be one of the variables contributing to their excess food consumption. |
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Authors:
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Gene-Jack Wang; Nora D Volkow; Christoph Felder; Joanna S Fowler; Alejandro V Levy; Naomi R Pappas; Christopher T Wong; Wei Zhu; Noelwah Netusil |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroreport Volume: 13 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-01 Completed Date: 2002-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1151-5 Citation Subset: IM |
Affiliation:
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Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Afferent Pathways / metabolism*, physiopathology, radionuclide imaging Appetite Regulation / physiology* Body Mass Index Brain Mapping Eating Disorders / metabolism*, physiopathology, radionuclide imaging Energy Metabolism / physiology Female Fluorodeoxyglucose F18 / diagnostic use Functional Laterality / physiology Glucose / metabolism Humans Male Middle Aged Mouth / innervation* Obesity, Morbid / metabolism*, physiopathology*, radionuclide imaging Somatosensory Cortex / metabolism*, physiopathology, radionuclide imaging Tomography, Emission-Computed Up-Regulation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA 06891-02/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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