| Enhanced renal tubular calcium reabsorption independent of parathormone activity, in children on long term anticonvulsant therapy. | |
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MedLine Citation:
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PMID: 6246708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A significant reduction in the urinary calcium-creatinine ratio, was found in thirty-four ambulatory epileptic children on long term anticonvulsant therapy, studied during wintertime. No significant difference in the urinary excretion of cyclic AMP, phosphate or amino-acids was observed when the study-group was compared to an age-matched control group. Serum calcium and phosphate values were normal, but a significant increment in alkaline phosphatase was noted. Since there was no evidence of hyperactivity of the parathormone, it is suggested that the enhanced renal tubular calcium reabsorption in children on long term anticonvulsant therapy is a nonparathormone mediated phenomenon, possibly compensating for reduced calcium absorption in the gastrointestinal tract. |
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Authors:
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M Aladjem; M Shohat; S Orda; H Boichis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 69 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-07-28 Completed Date: 1980-07-28 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 311-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adolescent Amino Acids / urine Anticonvulsants / adverse effects*, therapeutic use Calcium / metabolism*, urine Child Cyclic AMP / urine Epilepsy / drug therapy Female Humans Kidney Tubules / metabolism* Male Parathyroid Hormone / blood Phosphates / urine |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anticonvulsants; 0/Parathyroid Hormone; 0/Phosphates; 60-92-4/Cyclic AMP; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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